Hi, 

Is it possible, with existing software, to extract signal changes at vertices, voxels, or ROIs for single trials, rather than across trials?  This would allow an examination of  intra-subject variability in BOLD response, habituation effects, etc...  Something like this was done by: Yamaguchi S, Hale LA, D'Esposito M, Knight RT (2004): Rapid prefrontal-hippocampal habituation to novel events. J Neurosci 24:5356-5363.

thanks,

Dara

Dara S. Manoach, Ph.D.

Psychiatric Neuroimaging

Massachusetts General Hospital

Charlestown Navy Yard

149 13th Street, Room 2608

Charlestown, MA 02129

email: dara@nmr.mgh.harvard.edu

phone: 617-724-6148

fax: 617-726-4078

http://nmr.mgh.harvard.edu/manoachlab

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