Dear Bruce,
The one I sent you were with diet .25. I reran it with .01 and now I can see minor non-linear shift ( see the attachment). 
I know that this registration is set up for the template one and I知 just trying to fins out the base parameter set for the subject to subject surface base registration. Since this is working perfectly for template base I assume by setting the right parameters I can get to something similar. The problem is that the curvature maps after registrations are so different that makes me believe that I知 still doing something wrong. I知 more than happy to try any other suggestion to fix this.

Best


-- 
Ray Razlighi, Ph.D.
Assistant Professor
Quantitative Neuroimaging Laboratory
Division of Cognitive Neuroscience
Department of Neurology
Columbia University

Alt: razlighi@gmail.com
Office Phone: 212-342-1352
Office Fax: 212-342-1838
Website: http://www.columbia.edu/cu/qnl/

On Nov 6, 2015, at 3:23 PM, Bruce Fischl <fischl@nmr.mgh.harvard.edu> wrote:

did you try setting dist to .01 or something very small? Note that we don't register individual surfaces to each other for a reason - the inverse variance weighting in the warp functional is critical to it being stable and accurate

cheers
Bruce

On Fri, 6 Nov 2015, Razlighi, Qolamreza R. wrote:

Dear Bruce, I did set the DIAG and ran it again with no luck. Below is the
output and attached please find the result.
Best[IMAGE]
ray@athens-b8-e8-56-47-e6-54:~\> tcsh
[athens-b8-e8-56-47-e6-54:~] ray% 
[athens-b8-e8-56-47-e6-54:~] ray% setenv DIAG 0x04040
[athens-b8-e8-56-47-e6-54:~] ray% 
[athens-b8-e8-56-47-e6-54:~/Data/P00001613/FreeSurferClean] ray% cd surf/
[athens-b8-e8-56-47-e6-54:P00001613/FreeSurferClean/surf] ray% 
[athens-b8-e8-56-47-e6-54:P00001613/FreeSurferClean/surf] ray% mris_register
-1 -parea 0 -curv -dist .25 lh.sphere
../../../P00001639/FreeSurferClean/surf/lh.sphere lh.sphere_dis25_parea0.reg
treating target as a single subject's surface...
using l_parea = 0.000
using smoothwm curvature for final alignment
l_dist = 0.250
$Id: mris_register.c,v 1.59 2011/03/02 00:04:33 nicks Exp $
  $Id: mrisurf.c,v 1.693.2.7 2013/05/12 22:28:01 nicks Exp $
reading surface from lh.sphere...
reading spherical surface
../../../P00001639/FreeSurferClean/surf/lh.sphere...
curvature mean = -0.000, std = 1.000
computing parameterization for surface
../../../P00001639/FreeSurferClean/surf/lh.inflated.H...
curvature mean = 0.000, std = 0.566
computing parameterization for surface
../../../P00001639/FreeSurferClean/surf/lh.sulc...
curvature mean = -0.030, std = 0.282
computing parameterization for surface
../../../P00001639/FreeSurferClean/surf/lh.smoothwm...
MRISregister() -------
max_passes = 4 
min_degrees = 0.500000 
max_degrees = 64.000000 
nangles = 8 
tol=5.0e-01, sigma=0.0, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=1.000, l_dist=0.250
using quadratic fit line minimization
complete_dist_mat 0
rms 0
smooth_averages 0
remove_neg 0
ico_order 0
which_surface 0
target_radius 0.000000
nfields 0
scale 0.000000
desired_rms_height -1.000000
momentum 0.950000
nbhd_size -10
max_nbrs 10
niterations 25
nsurfaces 0
SURFACES 3
flags 16 (10)
use curv 16
no sulc 0
no rigid align 0
mris->nsize 1
mris->hemisphere 0
randomSeed 0
--------------------
tol=5.0e-01, sigma=0.0, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=1.000, l_dist=0.250
using quadratic fit line minimization
1 Reading lh.sulc
curvature mean = 0.000, std = 0.583
reading precomputed curvature from lh.sulc
blurring surfaces with sigma=4.00...
done.
curvature mean = 0.044, std = 0.847
curvature mean = 0.022, std = 0.852
finding optimal rigid alignment
Starting MRISrigidBodyAlignGlobal()
000: dt: 0.000, sse: 135379.3 (0.279, 21.6, 0.412, 0.853), neg: 0
(%0.00:%0.00), avgs: 1024
scanning 64.00 degree nbhd, min sse = 95165.92
(+64.00, +64.00, -64.00), min @ (0.00, 0.00, 0.00) = 95165.9   
scanning 32.00 degree nbhd, min sse = 95165.92
(+32.00, +32.00, -32.00), min @ (8.00, 0.00, 0.00) = 90765.7   
  d=32.00 min @ (8.00, 0.00, 0.00) sse = 90765.7, tmin=1.1635
min sse = 90765.70 at (8.00, 0.00, 0.00)
001: dt: 0.000, sse: 130979.1 (0.279, 21.6, 0.412, 0.833), neg: 0
(%0.00:%0.00), avgs: 1024
scanning 16.00 degree nbhd, min sse = 90765.70
(+16.00, +16.00, -16.00), min @ (-4.00, -4.00, 0.00) = 87371.6   
  d=16.00 min @ (-4.00, -4.00, 0.00) sse = 87371.6, tmin=1.7380
min sse = 87371.58 at (-4.00, -4.00, 0.00)
002: dt: 0.000, sse: 127584.9 (0.279, 21.6, 0.412, 0.817), neg: 0
(%0.00:%0.00), avgs: 1024
scanning 8.00 degree nbhd, min sse = 87371.58
(+8.00, +8.00, -8.00), min @ (-2.00, 0.00, 0.00) = 86754.0   
  d=8.00 min @ (-2.00, 0.00, 0.00) sse = 86754.0, tmin=2.3264
min sse = 86754.03 at (-2.00, 0.00, 0.00)
003: dt: 0.000, sse: 126967.4 (0.279, 21.6, 0.412, 0.814), neg: 0
(%0.00:%0.00), avgs: 1024
scanning 4.00 degree nbhd, min sse = 86754.03
(+4.00, +4.00, -4.00), min @ (1.00, 1.00, 0.00) = 86449.9   
  d=4.00 min @ (1.00, 1.00, 0.00) sse = 86449.9, tmin=2.9298
min sse = 86449.91 at (1.00, 1.00, 0.00)
004: dt: 0.000, sse: 126663.3 (0.279, 21.6, 0.412, 0.813), neg: 0
(%0.00:%0.00), avgs: 1024
scanning 2.00 degree nbhd, min sse = 86449.91
(+2.00, +2.00, -2.00), min @ (0.00, -0.50, 0.50) = 86436.5   
  d=2.00 min @ (0.00, -0.50, 0.50) sse = 86436.5, tmin=3.5333
min sse = 86436.46 at (0.00, -0.50, 0.50)
005: dt: 0.000, sse: 126649.8 (0.279, 21.6, 0.412, 0.813), neg: 0
(%0.00:%0.00), avgs: 1024
scanning 1.00 degree nbhd, min sse = 86436.45
(+1.00, +1.00, -1.00), min @ (0.00, 0.25, -0.25) = 86423.4   
  d=1.00 min @ (0.00, 0.25, -0.25) sse = 86423.4, tmin=4.1242
min sse = 86423.41 at (0.00, 0.25, -0.25)
006: dt: 0.000, sse: 126636.8 (0.279, 21.6, 0.412, 0.813), neg: 0
(%0.00:%0.00), avgs: 1024
scanning 0.50 degree nbhd, min sse = 86423.41
(+0.50, +0.50, -0.50), min @ (0.00, 0.00, 0.00) = 86423.4   
MRISrigidBodyAlignGlobal() done   4.71 min
tol=5.0e-01, sigma=4.0, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=1.000, l_dist=0.250
using quadratic fit line minimization
nlarea/corr = 1.000
integrating with navgs=1024 and tol=5.002e-01
007: dt: 241.975, sse: 109215.9 (0.308, 23.5, 0.429, 0.709), neg: 48
(%0.00:%0.01), avgs: 1024
008: dt: 117.533, sse: 99575.6 (0.298, 23.7, 0.432, 0.651), neg: 50
(%0.00:%0.01), avgs: 1024
009: dt: 136.508, sse: 95352.8 (0.305, 24.1, 0.436, 0.620), neg: 101
(%0.00:%0.02), avgs: 1024
010: dt: 105.985, sse: 92867.4 (0.303, 24.8, 0.442, 0.597), neg: 176
(%0.01:%0.03), avgs: 1024
011: dt: 149.343, sse: 90631.3 (0.311, 25.4, 0.448, 0.573), neg: 334
(%0.01:%0.06), avgs: 1024
012: dt: 85.796, sse: 89225.0 (0.312, 25.9, 0.453, 0.557), neg: 439
(%0.02:%0.08), avgs: 1024
013: dt: 177.745, sse: 87895.2 (0.321, 26.7, 0.460, 0.536), neg: 690
(%0.04:%0.13), avgs: 1024
014: dt: 66.370, sse: 87281.5 (0.322, 27.0, 0.463, 0.527), neg: 782
(%0.05:%0.14), avgs: 1024
015: dt: 236.440, sse: 86602.8 (0.331, 27.8, 0.472, 0.508), neg: 1155
(%0.08:%0.22), avgs: 1024
016: dt: 69.671, sse: 86419.9 (0.332, 28.0, 0.474, 0.502), neg: 1213
(%0.09:%0.23), avgs: 1024
integrating with navgs=256 and tol=2.505e-01
017: dt: 122.246, sse: 82435.7 (0.347, 29.5, 0.492, 0.436), neg: 2026
(%0.16:%0.43), avgs: 256
018: dt: 69.015, sse: 81795.8 (0.350, 29.8, 0.499, 0.417), neg: 1971
(%0.12:%0.42), avgs: 256
019: dt: 36.896, sse: 81619.9 (0.353, 30.1, 0.502, 0.407), neg: 2059
(%0.12:%0.44), avgs: 256
integrating with navgs=64 and tol=1.260e-01
020: dt: 33.532, sse: 80387.5 (0.362, 30.7, 0.513, 0.370), neg: 2300
(%0.10:%0.49), avgs: 64
021: dt: 9.860, sse: 80325.9 (0.364, 30.9, 0.516, 0.362), neg: 2391
(%0.10:%0.51), avgs: 64
integrating with navgs=16 and tol=6.442e-02
022: dt: 6.761, sse: 80080.1 (0.368, 30.9, 0.520, 0.348), neg: 1935
(%0.07:%0.41), avgs: 16
023: dt: 0.929, sse: 80074.6 (0.368, 31.0, 0.521, 0.347), neg: 1928
(%0.06:%0.40), avgs: 16
integrating with navgs=4 and tol=3.494e-02
024: dt: 1.444, sse: 80034.9 (0.370, 31.0, 0.522, 0.343), neg: 1734
(%0.06:%0.35), avgs: 4
025: dt: 0.556, sse: 80028.6 (0.370, 31.0, 0.523, 0.341), neg: 1762
(%0.05:%0.36), avgs: 4
integrating with navgs=1 and tol=2.210e-02
026: dt: 0.066, sse: 80027.9 (0.370, 31.0, 0.523, 0.341), neg: 1753
(%0.05:%0.36), avgs: 1
integrating with navgs=0 and tol=1.562e-02
027: dt: 0.050, sse: 80016.6 (0.370, 31.0, 0.523, 0.341), neg: 1716
(%0.05:%0.33), avgs: 0
blurring surfaces with sigma=2.00...
done.
curvature mean = 0.035, std = 0.927
curvature mean = 0.011, std = 0.928
tol=5.0e-01, sigma=2.0, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=1.000, l_dist=0.250
using quadratic fit line minimization
nlarea/corr = 1.000
integrating with navgs=1024 and tol=5.002e-01
028: dt: 137.600, sse: 83361.7 (0.371, 31.1, 0.524, 0.373), neg: 1570
(%0.04:%0.30), avgs: 1024
integrating with navgs=256 and tol=2.505e-01
029: dt: 16.658, sse: 83344.4 (0.372, 31.1, 0.526, 0.370), neg: 1484
(%0.03:%0.28), avgs: 256
integrating with navgs=64 and tol=1.260e-01
030: dt: 10.485, sse: 83245.6 (0.375, 31.4, 0.530, 0.359), neg: 1316
(%0.03:%0.23), avgs: 64
integrating with navgs=16 and tol=6.442e-02
031: dt: 4.712, sse: 83112.1 (0.379, 31.6, 0.534, 0.346), neg: 1194
(%0.02:%0.19), avgs: 16
032: dt: 0.845, sse: 83109.5 (0.380, 31.6, 0.535, 0.344), neg: 1176
(%0.02:%0.19), avgs: 16
integrating with navgs=4 and tol=3.494e-02
033: dt: 0.700, sse: 83081.6 (0.381, 31.6, 0.536, 0.340), neg: 1147
(%0.02:%0.18), avgs: 4
integrating with navgs=1 and tol=2.210e-02
034: dt: 0.517, sse: 83064.4 (0.382, 31.7, 0.536, 0.338), neg: 1204
(%0.02:%0.19), avgs: 1
integrating with navgs=0 and tol=1.562e-02
035: dt: 0.041, sse: 83050.5 (0.382, 31.7, 0.537, 0.337), neg: 1173
(%0.02:%0.18), avgs: 0
036: dt: 0.042, sse: 83039.7 (0.382, 31.7, 0.537, 0.337), neg: 1171
(%0.02:%0.18), avgs: 0
blurring surfaces with sigma=1.00...
done.
curvature mean = 0.033, std = 0.955
curvature mean = 0.005, std = 0.964
tol=5.0e-01, sigma=1.0, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=1.000, l_dist=0.250
using quadratic fit line minimization
nlarea/corr = 1.000
integrating with navgs=1024 and tol=5.002e-01
037: dt: 115.451, sse: 87076.6 (0.383, 31.7, 0.537, 0.378), neg: 1086
(%0.02:%0.16), avgs: 1024
integrating with navgs=256 and tol=2.505e-01
038: dt: 0.037, sse: 87076.2 (0.383, 31.7, 0.537, 0.378), neg: 1087
(%0.02:%0.16), avgs: 256
integrating with navgs=64 and tol=1.260e-01
039: dt: 6.000, sse: 87067.2 (0.385, 31.9, 0.540, 0.372), neg: 1155
(%0.02:%0.17), avgs: 64
integrating with navgs=16 and tol=6.442e-02
040: dt: 0.771, sse: 87047.6 (0.385, 32.0, 0.540, 0.370), neg: 1166
(%0.02:%0.17), avgs: 16
integrating with navgs=4 and tol=3.494e-02
041: dt: 0.926, sse: 86979.7 (0.387, 32.1, 0.542, 0.365), neg: 1169
(%0.02:%0.17), avgs: 4
042: dt: 0.550, sse: 86964.0 (0.388, 32.2, 0.543, 0.362), neg: 1182
(%0.02:%0.17), avgs: 4
integrating with navgs=1 and tol=2.210e-02
043: dt: 0.255, sse: 86957.1 (0.389, 32.2, 0.544, 0.360), neg: 1203
(%0.02:%0.18), avgs: 1
integrating with navgs=0 and tol=1.562e-02
044: dt: 0.035, sse: 86943.6 (0.389, 32.2, 0.544, 0.359), neg: 1219
(%0.02:%0.17), avgs: 0
blurring surfaces with sigma=0.50...
done.
curvature mean = 0.033, std = 0.965
curvature mean = 0.001, std = 0.983
tol=5.0e-01, sigma=0.5, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=1.000, l_dist=0.250
using quadratic fit line minimization
nlarea/corr = 1.000
integrating with navgs=1024 and tol=5.002e-01
045: dt: 39.869, sse: 89122.8 (0.389, 32.2, 0.544, 0.381), neg: 1239
(%0.02:%0.18), avgs: 1024
integrating with navgs=256 and tol=2.505e-01
046: dt: 0.040, sse: 89122.7 (0.389, 32.2, 0.544, 0.381), neg: 1239
(%0.02:%0.18), avgs: 256
integrating with navgs=64 and tol=1.260e-01
047: dt: 0.015, sse: 89122.7 (0.389, 32.2, 0.544, 0.381), neg: 1239
(%0.02:%0.18), avgs: 64
integrating with navgs=16 and tol=6.442e-02
048: dt: 0.763, sse: 89114.0 (0.390, 32.3, 0.545, 0.379), neg: 1259
(%0.02:%0.18), avgs: 16
integrating with navgs=4 and tol=3.494e-02
049: dt: 0.531, sse: 89093.1 (0.391, 32.4, 0.546, 0.376), neg: 1286
(%0.02:%0.18), avgs: 4
integrating with navgs=1 and tol=2.210e-02
050: dt: 0.280, sse: 89084.5 (0.392, 32.4, 0.547, 0.374), neg: 1315
(%0.02:%0.19), avgs: 1
integrating with navgs=0 and tol=1.562e-02
051: dt: 0.128, sse: 89052.0 (0.393, 32.5, 0.547, 0.372), neg: 1300
(%0.04:%0.18), avgs: 0
052: dt: 0.032, sse: 89024.1 (0.392, 32.5, 0.547, 0.372), neg: 1329
(%0.02:%0.18), avgs: 0
053: dt: 0.033, sse: 89014.9 (0.393, 32.5, 0.547, 0.371), neg: 1377
(%0.02:%0.19), avgs: 0
2 Reading smoothwm
curvature mean = -0.027, std = 0.269
calculating curvature of smoothwm surface
tol=1.0e+00, sigma=0.5, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=0.050, l_spring=0.500, l_dist=0.250
using quadratic fit line minimization
blurring surfaces with sigma=4.00...
done.
curvature mean = 0.089, std = 0.338
curvature mean = 0.065, std = 0.378
tol=1.0e+00, sigma=4.0, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=0.050, l_spring=0.500, l_dist=0.250
using quadratic fit line minimization
nlarea/corr = 20.000
integrating with navgs=1024 and tol=1.000e+00
054: dt: 3.299, sse: 745272.2 (0.384, 31.8, 0.538, 0.745), neg: 1168
(%0.04:%0.21), avgs: 1024
055: dt: 2.605, sse: 738110.4 (0.379, 31.4, 0.532, 0.748), neg: 740
(%0.01:%0.11), avgs: 1024
integrating with navgs=256 and tol=5.010e-01
056: dt: 2.945, sse: 732954.1 (0.377, 31.2, 0.529, 0.751), neg: 774
(%0.02:%0.13), avgs: 256
057: dt: 2.657, sse: 728543.9 (0.374, 30.9, 0.526, 0.753), neg: 511
(%0.01:%0.08), avgs: 256
058: dt: 2.797, sse: 724908.4 (0.373, 30.8, 0.523, 0.756), neg: 551
(%0.01:%0.09), avgs: 256
059: dt: 2.740, sse: 721596.7 (0.371, 30.6, 0.521, 0.758), neg: 404
(%0.00:%0.06), avgs: 256
integrating with navgs=64 and tol=2.519e-01
060: dt: 0.737, sse: 720241.4 (0.370, 30.4, 0.520, 0.758), neg: 307
(%0.00:%0.05), avgs: 64
integrating with navgs=16 and tol=1.288e-01
061: dt: 6.542, sse: 716147.8 (0.370, 30.3, 0.518, 0.758), neg: 559
(%0.01:%0.07), avgs: 16
062: dt: 1.625, sse: 712606.1 (0.367, 29.9, 0.514, 0.757), neg: 151
(%0.00:%0.02), avgs: 16
063: dt: 11.631, sse: 707697.2 (0.368, 29.9, 0.513, 0.757), neg: 580
(%0.02:%0.06), avgs: 16
064: dt: 1.462, sse: 703515.8 (0.365, 29.3, 0.508, 0.756), neg: 88
(%0.00:%0.01), avgs: 16
065: dt: 29.856, sse: 694749.9 (0.368, 29.3, 0.505, 0.756), neg: 702
(%0.03:%0.07), avgs: 16
066: dt: 1.308, sse: 688816.4 (0.363, 28.4, 0.499, 0.756), neg: 56
(%0.00:%0.01), avgs: 16
067: dt: 25.204, sse: 684304.4 (0.364, 28.4, 0.496, 0.756), neg: 526
(%0.02:%0.06), avgs: 16
068: dt: 1.261, sse: 680584.3 (0.361, 27.8, 0.492, 0.756), neg: 60
(%0.00:%0.01), avgs: 16
069: dt: 10.120, sse: 679053.8 (0.362, 27.8, 0.492, 0.756), neg: 168
(%0.00:%0.01), avgs: 16
070: dt: 1.667, sse: 677616.7 (0.361, 27.6, 0.490, 0.756), neg: 51
(%0.00:%0.00), avgs: 16
071: dt: 6.724, sse: 676628.9 (0.361, 27.6, 0.490, 0.756), neg: 124
(%0.00:%0.01), avgs: 16
072: dt: 1.678, sse: 675656.8 (0.360, 27.5, 0.489, 0.756), neg: 52
(%0.00:%0.01), avgs: 16
073: dt: 8.216, sse: 674570.9 (0.361, 27.5, 0.488, 0.757), neg: 133
(%0.00:%0.01), avgs: 16
074: dt: 1.694, sse: 673512.5 (0.360, 27.3, 0.487, 0.757), neg: 53
(%0.00:%0.01), avgs: 16
075: dt: 1.764, sse: 673109.5 (0.360, 27.3, 0.487, 0.757), neg: 50
(%0.00:%0.00), avgs: 16
integrating with navgs=4 and tol=6.988e-02
076: dt: 22.423, sse: 670854.9 (0.362, 27.2, 0.485, 0.742), neg: 200
(%0.00:%0.02), avgs: 4
077: dt: 1.661, sse: 669613.8 (0.361, 27.0, 0.484, 0.743), neg: 95
(%0.00:%0.01), avgs: 4
078: dt: 4.100, sse: 668786.9 (0.361, 27.0, 0.483, 0.744), neg: 92
(%0.00:%0.01), avgs: 4
079: dt: 3.000, sse: 668304.8 (0.361, 27.0, 0.483, 0.744), neg: 102
(%0.00:%0.01), avgs: 4
080: dt: 1.848, sse: 667791.1 (0.361, 26.9, 0.482, 0.744), neg: 77
(%0.00:%0.01), avgs: 4
081: dt: 5.400, sse: 667120.4 (0.361, 26.9, 0.482, 0.745), neg: 105
(%0.00:%0.01), avgs: 4
082: dt: 1.967, sse: 666614.0 (0.361, 26.8, 0.481, 0.745), neg: 73
(%0.00:%0.01), avgs: 4
083: dt: 4.462, sse: 666103.5 (0.361, 26.8, 0.481, 0.745), neg: 103
(%0.00:%0.01), avgs: 4
084: dt: 2.154, sse: 665621.2 (0.361, 26.8, 0.481, 0.745), neg: 76
(%0.00:%0.01), avgs: 4
085: dt: 2.615, sse: 665218.2 (0.361, 26.7, 0.480, 0.745), neg: 74
(%0.00:%0.01), avgs: 4
integrating with navgs=1 and tol=4.419e-02
086: dt: 2.667, sse: 664951.9 (0.361, 26.7, 0.480, 0.744), neg: 76
(%0.00:%0.01), avgs: 1
integrating with navgs=0 and tol=3.125e-02
087: dt: 0.506, sse: 664875.2 (0.361, 26.7, 0.480, 0.743), neg: 76
(%0.00:%0.01), avgs: 0
blurring surfaces with sigma=2.00...
done.
curvature mean = 0.090, std = 0.502
curvature mean = 0.020, std = 0.575
tol=1.0e+00, sigma=2.0, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=0.050, l_spring=0.500, l_dist=0.250
using quadratic fit line minimization
nlarea/corr = 20.000
integrating with navgs=1024 and tol=1.000e+00
088: dt: 6.568, sse: 665480.4 (0.359, 26.7, 0.479, 0.937), neg: 270
(%0.02:%0.04), avgs: 1024
integrating with navgs=256 and tol=5.010e-01
089: dt: 1.744, sse: 664408.7 (0.359, 26.6, 0.478, 0.938), neg: 58
(%0.00:%0.01), avgs: 256
integrating with navgs=64 and tol=2.519e-01
090: dt: 6.774, sse: 663527.8 (0.360, 26.6, 0.478, 0.941), neg: 186
(%0.01:%0.03), avgs: 64
integrating with navgs=16 and tol=1.288e-01
091: dt: 1.450, sse: 662806.6 (0.359, 26.5, 0.477, 0.939), neg: 45
(%0.00:%0.00), avgs: 16
integrating with navgs=4 and tol=6.988e-02
092: dt: 6.720, sse: 662316.9 (0.359, 26.4, 0.477, 0.920), neg: 63
(%0.00:%0.01), avgs: 4
093: dt: 4.200, sse: 662053.0 (0.360, 26.5, 0.477, 0.913), neg: 85
(%0.00:%0.01), avgs: 4
integrating with navgs=1 and tol=4.419e-02
094: dt: 0.903, sse: 661962.4 (0.360, 26.5, 0.477, 0.910), neg: 79
(%0.00:%0.01), avgs: 1
integrating with navgs=0 and tol=3.125e-02
095: dt: 0.110, sse: 661952.2 (0.360, 26.5, 0.477, 0.909), neg: 73
(%0.00:%0.01), avgs: 0
blurring surfaces with sigma=1.00...
done.
curvature mean = 0.091, std = 0.611
curvature mean = 0.012, std = 0.719
tol=1.0e+00, sigma=1.0, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=0.050, l_spring=0.500, l_dist=0.250
using quadratic fit line minimization
nlarea/corr = 20.000
integrating with navgs=1024 and tol=1.000e+00
096: dt: 8.627, sse: 661315.6 (0.359, 26.4, 0.476, 1.011), neg: 227
(%0.02:%0.04), avgs: 1024
integrating with navgs=256 and tol=5.010e-01
097: dt: 1.786, sse: 660256.5 (0.358, 26.3, 0.475, 1.012), neg: 66
(%0.00:%0.01), avgs: 256
integrating with navgs=64 and tol=2.519e-01
098: dt: 5.077, sse: 659704.2 (0.359, 26.3, 0.474, 1.011), neg: 149
(%0.01:%0.02), avgs: 64
integrating with navgs=16 and tol=1.288e-01
099: dt: 1.431, sse: 659144.8 (0.358, 26.2, 0.474, 1.009), neg: 44
(%0.00:%0.00), avgs: 16
integrating with navgs=4 and tol=6.988e-02
100: dt: 2.714, sse: 658944.9 (0.358, 26.2, 0.474, 0.996), neg: 47
(%0.00:%0.00), avgs: 4
integrating with navgs=1 and tol=4.419e-02
101: dt: 0.075, sse: 658940.8 (0.358, 26.2, 0.474, 0.995), neg: 47
(%0.00:%0.00), avgs: 1
integrating with navgs=0 and tol=3.125e-02
102: dt: 0.054, sse: 658935.4 (0.358, 26.2, 0.474, 0.994), neg: 47
(%0.00:%0.00), avgs: 0
blurring surfaces with sigma=0.50...
done.
curvature mean = 0.092, std = 0.682
curvature mean = 0.004, std = 0.828
tol=1.0e+00, sigma=0.5, host=athen, nav=1024, nbrs=1, l_extern=10000.000,
l_nlarea=1.000, l_corr=0.050, l_spring=0.500, l_dist=0.250
using quadratic fit line minimization
nlarea/corr = 20.000
integrating with navgs=1024 and tol=1.000e+00
103: dt: 27.636, sse: 656331.2 (0.358, 26.1, 0.472, 1.092), neg: 165
(%0.01:%0.03), avgs: 1024
integrating with navgs=256 and tol=5.010e-01
104: dt: 2.000, sse: 654661.2 (0.357, 25.9, 0.470, 1.083), neg: 82
(%0.00:%0.01), avgs: 256
integrating with navgs=64 and tol=2.519e-01
105: dt: 3.105, sse: 653928.0 (0.357, 25.8, 0.469, 1.076), neg: 67
(%0.00:%0.01), avgs: 64
integrating with navgs=16 and tol=1.288e-01
106: dt: 2.292, sse: 653418.9 (0.357, 25.8, 0.469, 1.066), neg: 53
(%0.00:%0.01), avgs: 16
integrating with navgs=4 and tol=6.988e-02
107: dt: 1.047, sse: 653125.0 (0.357, 25.8, 0.469, 1.057), neg: 35
(%0.00:%0.00), avgs: 4
integrating with navgs=1 and tol=4.419e-02
108: dt: 0.724, sse: 653027.9 (0.357, 25.8, 0.469, 1.047), neg: 36
(%0.00:%0.00), avgs: 1
integrating with navgs=0 and tol=3.125e-02
109: dt: 0.064, sse: 653009.2 (0.357, 25.8, 0.469, 1.044), neg: 34
(%0.00:%0.00), avgs: 0
Removing remaining folds...
tol=1.0e-01, sigma=0.5, host=athen, nav=64, nbrs=1, l_extern=10000.000,
l_nlarea=100.000, l_corr=0.001, l_spring=0.005, l_dist=0.002
using quadratic fit line minimization
nlarea/corr = 199999.984
integrating with navgs=64 and tol=2.519e-02
110: dt: 5.514, sse: 187681.1 (0.355, 25.8, 0.466, 1.062), neg: 85
(%0.00:%0.01), avgs: 64
111: dt: 1.735, sse: 184602.0 (0.355, 25.7, 0.466, 1.064), neg: 16
(%0.00:%0.00), avgs: 64
112: dt: 2.802, sse: 182518.2 (0.354, 25.7, 0.466, 1.068), neg: 16
(%0.00:%0.00), avgs: 64
113: dt: 3.973, sse: 180638.1 (0.355, 25.8, 0.466, 1.072), neg: 16
(%0.00:%0.00), avgs: 64
114: dt: 2.388, sse: 179649.5 (0.355, 25.8, 0.467, 1.075), neg: 20
(%0.00:%0.00), avgs: 64
115: dt: 3.088, sse: 178962.5 (0.355, 25.9, 0.467, 1.079), neg: 28
(%0.00:%0.00), avgs: 64
116: dt: 2.775, sse: 178633.9 (0.356, 26.0, 0.468, 1.082), neg: 36
(%0.00:%0.00), avgs: 64
117: dt: 0.831, sse: 178379.4 (0.356, 26.0, 0.468, 1.083), neg: 37
(%0.00:%0.00), avgs: 64
118: dt: 2.731, sse: 178093.2 (0.356, 26.1, 0.469, 1.087), neg: 52
(%0.00:%0.00), avgs: 64
119: dt: 0.606, sse: 177994.0 (0.356, 26.1, 0.469, 1.088), neg: 46
(%0.00:%0.00), avgs: 64
120: dt: 0.250, sse: 177987.2 (0.356, 26.1, 0.469, 1.088), neg: 48
(%0.00:%0.00), avgs: 64
integrating with navgs=16 and tol=1.288e-02
121: dt: 0.230, sse: 177851.4 (0.357, 26.1, 0.470, 1.089), neg: 46
(%0.00:%0.00), avgs: 16
122: dt: 0.031, sse: 177844.3 (0.357, 26.1, 0.470, 1.089), neg: 45
(%0.00:%0.00), avgs: 16
integrating with navgs=4 and tol=6.988e-03
123: dt: 0.013, sse: 177801.5 (0.357, 26.1, 0.470, 1.089), neg: 38
(%0.00:%0.00), avgs: 4
124: dt: 0.014, sse: 177784.2 (0.357, 26.1, 0.470, 1.089), neg: 32
(%0.00:%0.00), avgs: 4
125: dt: 0.014, sse: 177779.8 (0.357, 26.1, 0.470, 1.089), neg: 31
(%0.00:%0.00), avgs: 4
integrating with navgs=1 and tol=4.419e-03
126: dt: 0.000, sse: 177779.8 (0.357, 26.1, 0.470, 1.089), neg: 31
(%0.00:%0.00), avgs: 1
integrating with navgs=0 and tol=3.125e-03
127: dt: 0.000, sse: 177746.4 (0.357, 26.1, 0.470, 1.089), neg: 30
(%0.00:%0.00), avgs: 0
128: dt: 0.000, sse: 177734.2 (0.357, 26.1, 0.470, 1.089), neg: 28
(%0.00:%0.00), avgs: 0
129: dt: 0.000, sse: 177734.2 (0.357, 26.1, 0.470, 1.089), neg: 28
(%0.00:%0.00), avgs: 0
registration took 0.25 hours
MRISregister() return, current seed 0
expanding nbhd size to 1
writing registered surface to lh.sphere_dis25_parea0.reg...
registration took 0.25 hours
[athens-b8-e8-56-47-e6-54:P00001613/FreeSurferClean/surf] ray% 
 
-- 
Ray Razlighi, Ph.D.
Assistant Professor
Quantitative Neuroimaging Laboratory
Division of Cognitive Neuroscience
Department of Neurology
Columbia University
Alt: razlighi@gmail.com
Office Phone: 212-342-1352
Office Fax: 212-342-1838
Website: http://www.columbia.edu/cu/qnl/
On Nov 6, 2015, at 2:16 PM, Bruce Fischl <fischl@nmr.mgh.harvard.edu> wrote:

     Hi Ray

     try doing:

     setenv DIAG 0x04040

     then run it again and send me the output

     Bruce

     On Fri, 6 Nov 2015, Razlighi, Qolamreza R. wrote:

           Dear Bruce, Thank again for your kind help. I知
           running version 5.1.0. 
           Below is the output of the command.
           I also ran it with parea=0 but almost no change in
           the result (see the
           attachment-1)
           I also plot the sluci map for comparison (see the
           attachment-2) but still
           not satisfactory.[IMAGE][IMAGE] 
           Best
           ~/Data/P00001613/FreeSurferClean/surf\>
           mris_register -1 -curv -dist .25
           lh.sphere
           ../../../P00001639/FreeSurferClean/surf/lh.sphere
           lh.sphere_dis25.reg
           treating target as a single subject's surface...
           using smoothwm curvature for final alignment
           l_dist = 0.250
           $Id: mris_register.c,v 1.59 2011/03/02 00:04:33
           nicks Exp $
             $Id: mrisurf.c,v 1.693.2.7 2013/05/12 22:28:01
           nicks Exp $
           reading surface from lh.sphere...
           reading spherical surface
           ../../../P00001639/FreeSurferClean/surf/lh.sphere...
           curvature mean = -0.000, std = 1.000
           computing parameterization for surface
           ../../../P00001639/FreeSurferClean/surf/lh.inflated.H...
           curvature mean = 0.000, std = 0.566
           computing parameterization for surface
           ../../../P00001639/FreeSurferClean/surf/lh.sulc...
           curvature mean = -0.030, std = 0.282
           computing parameterization for surface
           ../../../P00001639/FreeSurferClean/surf/lh.smoothwm...
           MRISregister() -------
           max_passes = 4 
           min_degrees = 0.500000 
           max_degrees = 64.000000 
           nangles = 8 
           tol=5.0e-01, sigma=0.0, host=unkno, nav=1024,
           nbrs=1, l_extern=10000.000,
           l_parea=0.100, l_nlarea=1.000, l_corr=1.000,
           l_dist=0.250
           using quadratic fit line minimization
           complete_dist_mat 0
           rms 0
           smooth_averages 0
           remove_neg 0
           ico_order 0
           which_surface 0
           target_radius 0.000000
           nfields 0
           scale 0.000000
           desired_rms_height -1.000000
           momentum 0.950000
           nbhd_size -10
           max_nbrs 10
           niterations 25
           nsurfaces 0
           SURFACES 3
           flags 16 (10)
           use curv 16
           no sulc 0
           no rigid align 0
           mris->nsize 1
           mris->hemisphere 0
           randomSeed 0
           --------------------
           tol=5.0e-01, sigma=0.0, host=unkno, nav=1024,
           nbrs=1, l_extern=10000.000,
           l_parea=0.100, l_nlarea=1.000, l_corr=1.000,
           l_dist=0.250
           using quadratic fit line minimization
           1 Reading lh.sulc
           curvature mean = 0.000, std = 0.583
           curvature mean = 0.044, std = 0.847
           curvature mean = 0.022, std = 0.852
           Starting MRISrigidBodyAlignGlobal()
             d=32.00 min @ (8.00, 0.00, 0.00) sse = 90765.7,
           tmin=0.9987
             d=16.00 min @ (-4.00, -4.00, 0.00) sse = 87371.6,
           tmin=1.5086
             d=8.00 min @ (-2.00, 0.00, 0.00) sse = 86754.0,
           tmin=2.0493
             d=4.00 min @ (1.00, 1.00, 0.00) sse = 86449.9,
           tmin=2.5976
             d=2.00 min @ (0.00, -0.50, 0.50) sse = 86436.5,
           tmin=3.1563
             d=1.00 min @ (0.00, 0.25, -0.25) sse = 86423.4,
           tmin=3.6949
           MRISrigidBodyAlignGlobal() done   4.24 min
           curvature mean = 0.036, std = 0.923
           curvature mean = 0.010, std = 0.931
           curvature mean = 0.036, std = 0.951
           curvature mean = 0.004, std = 0.967
           curvature mean = 0.036, std = 0.962
           curvature mean = 0.001, std = 0.984
           2 Reading smoothwm
           curvature mean = -0.027, std = 0.269
           tol=1.0e+00, sigma=0.5, host=unkno, nav=1024,
           nbrs=1, l_extern=10000.000,
           l_parea=0.100, l_nlarea=1.000, l_corr=0.050,
           l_spring=0.500, l_dist=0.250
           using quadratic fit line minimization
           curvature mean = 0.090, std = 0.337
           curvature mean = 0.059, std = 0.386
           curvature mean = 0.091, std = 0.507
           curvature mean = 0.020, std = 0.580
           curvature mean = 0.091, std = 0.618
           curvature mean = 0.011, std = 0.723
           curvature mean = 0.093, std = 0.681
           curvature mean = 0.004, std = 0.828
           MRISregister() return, current seed 0
           expanding nbhd size to 1
           writing registered surface to lh.sphere_dis25.reg...
           -- 
           Ray Razlighi, Ph.D.
           Assistant Professor
           Quantitative Neuroimaging Laboratory
           Division of Cognitive Neuroscience
           Department of Neurology
           Columbia University
           Alt: razlighi@gmail.com
           Office Phone: 212-342-1352
           Office Fax: 212-342-1838
           Website: http://www.columbia.edu/cu/qnl/
           On Nov 4, 2015, at 7:30 PM, Bruce Fischl
           <fischl@nmr.mgh.harvard.edu> wrote:

                Hi Ray

                what version of FS are you using? Can you send
           me the output of
                the command? The distance term will prevent the
           curvatures from
                deforming too much. You can set it much smaller
           and see what
                happens if you want. There may also be an area
           constraint.
                Trying using -parea 0 also (or something small)

                cheers
                Bruce

                On Wed, 4 Nov 2015, Razlighi, Qolamreza R.
           wrote:

                      Hi Bruce,
                      Thanks for reply. I thought after
           registering, the
                      source surface's curvature map should be
           very
                      similar to the target one. I don't see
           that here.
                      The registered surface has pretty much
           the same
                      curvature map only slightly shifted.
                      Am I missing something here?

                      Best

                      On Nov 4, 2015, at 5:56 PM, Bruce Fischl
                      <fischl@nmr.mgh.harvard.edu>
                      wrote:

                            Hi Ray

                            that sounds right. The way I
           visualize
                            these is using nmovie (which I
           think we
                            include in our distribution) and
                            flipping back and forth between the
                            different images showing the
           different
                            surfaces/curv maps.

                            Which inaccuracy are you referring
           to?

                            cheers
                            Bruce

                            On Wed, 4 Nov 2015, Razlighi,
           Qolamreza
                            R. wrote:

                                  Dear Bruce,
                                  I did run it again with
                                  option (-dist 0.25); however
                                  the result did not
                                  change much (See the
                                  attachment). These results
                                  do not seem right to me and
                                  I think I知 running the
                                  command correctly (see the
                                  first email). However,
                                  I知 not sure I知 visualizing
                                  the curvature maps
                                  correctly. I assume the
                                  lh.sphere.reg has the same
                                  vertices and facets as
                                  lh.sphere but slightly
                                  displaced in space to match
                                  the curvature and sulci map
                                  of the source
                                  surface to target surface.
                                  Therefore, I visualize the
                                  lh.sphere.reg by
                                  pulling the same lh.curv
                                  file from the source image.
                                  If this is wrong,
                                  please let me know how can I
                                  correctly visualize the
                                  lh.sphere.reg,
                                  otherwise I have no idea why
                                  this surface based
                                  registration produce such
                                  inaccurate results. Any
                                  comments or suggestion is
                                  greatly appreciated.
                                  Best
                                  [IMAGE]
                                  --
                                  Ray Razlighi, Ph.D.
                                  Assistant Professor
                                  Quantitative Neuroimaging
                                  Laboratory
                                  Division of Cognitive
                                  Neuroscience
                                  Department of Neurology
                                  Columbia University
                                  Alt: razlighi@gmail.com
                                  Office Phone: 212-342-1352
                                  Office Fax: 212-342-1838
                                  Website:
                                  http://www.columbia.edu/cu/qnl/
                                  On Nov 3, 2015, at 3:47 PM,
                                  Bruce Fischl
                                  <fischl@nmr.mgh.harvard.edu>
                                  wrote:

                                      Hi Ray

                                      the -1 means that the
                                  target is a single surface
                                  and not an
                                      atlas, but the
                                  registration is still
                                  nonlinear. The variances
                                      will all be 1 so you may
                                  have to play with the
                                  weights in the
                                      energy functional. We
                                  don't do this very much and
                                  it probably
                                      defaults to quite rigid.
                                  Try reducing the weight on
                                  the metric
                                      preservation term (e.g.
                                  -dist .25) if you want it to
                                  be more
                                      nonlinear

                                      cheers
                                      Bruce

                                      On Tue, 3 Nov 2015,
                                  Razlighi, Qolamreza R.
                                  wrote:

                                            Hi Guys,
                                            I read in the
                                  sidenote here
          (https://surfer.nmr.mgh.harvard.edu/fswiki/SurfaceRegAndTemplates

                                  )
                                            that
                                            inter-subject
                                  surface base registration
                                  using
                                            mris_register and
                                  -1 flag
                                            performs a sort of
                                  rigid registration. So I
                                  tried it
                                            between two of my
                                            subjects with the
                                  command below
                                            mris_register -1
                                  -curv
                                            P00001639/FreeSurferClean/surf/lh.sphere
                                            P00001639/FreeSurferClean/surf/lh.sphere
                                            lh.sphere3.reg
                                            and got the
                                  results (see the
                                  attachment). It is
                                            clear that the
                                  registration
                                            output is just a
                                  shifted version of the
                                  source.
                                            Having this
                                  confirmed I want
                                            to know if there
                                  is any way to force the
                                            mris_register to
                                  perform a complete
                                            non-linear surface
                                  based registration for
                                            inter-subjects
                                  registration the
                                            same way it does
                                  for template.
                                            I have to mention
                                  that I visualize the
                                            lh.sphere3.reg
                                  using freeview and
                                            loaded the sane
                                  lh.curv on that surface. I
                                  hope I知
                                            not doing anything
                                            stupid.

                                            [IMAGE]
                                            Best
                                            --
                                            Ray Razlighi,
                                  Ph.D.
                                            Assistant
                                  Professor
                                            Quantitative
                                  Neuroimaging Laboratory
                                            Division of
                                  Cognitive Neuroscience
                                            Department of
                                  Neurology
                                            Columbia
                                  University
                                            Alt:
                                  razlighi@gmail.com
                                            Office Phone:
                                  212-342-1352
                                            Office Fax:
                                  212-342-1838
                                            Website:
                                  http://www.columbia.edu/cu/qnl/

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                                      to you in error
                                      but does not contain
                                  patient information, please
                                  contact the
                                      sender and properly
                                      dispose of the e-mail.

                            _______________________________________________
                            Freesurfer mailing list
                            Freesurfer@nmr.mgh.harvard.edu
                 https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurf
           er

                            The information in this e-mail is
                            intended only for the person to
           whom it
                            is
                            addressed. If you believe this
           e-mail
                            was sent to you in error and the
           e-mail
                            contains patient information,
           please
                            contact the Partners Compliance
           HelpLine
                            at
                            http://www.partners.org/complianceline
           .
                            If the e-mail was sent to you in
           error
                            but does not contain patient
                            information, please contact the
           sender
                            and properly
                            dispose of the e-mail.

                      _______________________________________________
                      Freesurfer mailing list
                      Freesurfer@nmr.mgh.harvard.edu
                      https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

                _______________________________________________
                Freesurfer mailing list
                Freesurfer@nmr.mgh.harvard.edu
                https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

                The information in this e-mail is intended only
           for the person
                to whom it is
                addressed. If you believe this e-mail was sent
           to you in error
                and the e-mail
                contains patient information, please contact
           the Partners
                Compliance HelpLine at
                http://www.partners.org/complianceline . If the
           e-mail was sent
                to you in error
                but does not contain patient information,
           please contact the
                sender and properly
                dispose of the e-mail.

     _______________________________________________
     Freesurfer mailing list
     Freesurfer@nmr.mgh.harvard.edu
     https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

     The information in this e-mail is intended only for the person
     to whom it is
     addressed. If you believe this e-mail was sent to you in error
     and the e-mail
     contains patient information, please contact the Partners
     Compliance HelpLine at
     http://www.partners.org/complianceline . If the e-mail was sent
     to you in error
     but does not contain patient information, please contact the
     sender and properly
     dispose of the e-mail.
_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer


The information in this e-mail is intended only for the person to whom it is
addressed. If you believe this e-mail was sent to you in error and the e-mail
contains patient information, please contact the Partners Compliance HelpLine at
http://www.partners.org/complianceline . If the e-mail was sent to you in error
but does not contain patient information, please contact the sender and properly
dispose of the e-mail.