Dear Bruce, 

Thank you for the response. So, I more thing if I want to get the mean cortical thickness for whole brain I could simply take the mean between both hemisphere ? If I understood right from the FAQ. 

Q. I am trying to measure the global mean cortical thickness (i.e combined across hemispheres), how would I do this?

A: One suggestion is to use the surface area of each hemisphere as the weighting factor. In which case the global mean thickness including both hemispheres would be given by:

bh.thickness = ( (lh.thickness * lh.surfarea) + (rh.thickness * rh.surfarea) ) / (lh.surfarea + rh.surfarea)

If you use the values in the ?h.aparc.stats, it already factors out the 'unknown' region, so you don't have to do it yourself.


Regards, 

Nabin


On Sat, Jun 25, 2016 at 3:29 PM, Bruce Fischl <fischl@nmr.mgh.harvard.edu> wrote:
Hi Nabin

unless the areas are the same size, the mean of the areal means won't equal the overall mean.

cheers
Bruce

On Sat, 25 Jun 2016, Nabin Koirala wrote:

Hi freesurfer team, 
I extracted the cortical thickness values using aparcstats2table command and
I got the cortical thickness values for 34 regions and mean cortical
thickness for each hemisphere. But when I averaged the cortical thickness
from those 34 regions regions it was different than the mean cortical
thickness obtained by aparcstats2table. I would expect it to be the same or
very close but I checked it for more than 100 subjects and they are
significantly different. Am I missing something silly here ?

Thank you. 

Regards, 
Nabin


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