Thank you a lot, Bruce.
One quick follow-up question: is it really bad is to project the activations on not_the_same_subject_anatomy? For example (attached), I have ran recon-all for two normalized SPGRs ('ka' and 'nz'). The general shape of brains is similar, though the sulci / gyri are in different places / form. Now I project the activations of one of them ('ka') to anatomies of itself and of 'nz'. The difference is dramatic. Does my demo make sense?

On Mon, Mar 29, 2010 at 2:42 PM, Bruce Fischl <fischl@nmr.mgh.harvard.edu> wrote:

Hi Vadim

the only problem will be that you've introduced an extra interpolation and the associated smoothing into your data. I suspect it will reduce the accuracy of the models for things like thickness estimation, but otherwise should be fine for e.g. functional overlaying.

cheers
Bruce

On Mon, 29 Mar 2010, Vadim Axel wrote:

Dear experts,

I run my statistical analysis in SPM, while after coregistration I normalize
my data (SPGR and EPI). Since my models and activations images are based on
normalized data it's natural for me to use the normalized SPGR as an input
for freesurfer inflation. Is it a good enough? Since I run inflation for
each individual brain, I basically can do it for non-normalized anatomy,
which is preferable, I think. However, then the coordinates are not MNI /
Talariach. Attached the comparison of activations for normalized (left side)
vs. non-normalized. It looks pretty similar, though the brains look of
different shape. So, am I OK to do it on normalized brain?

Thanks for help,
Vadim

The information in this e-mail is intended only for the person to whom it is
addressed. If you believe this e-mail was sent to you in error and the e-mail
contains patient information, please contact the Partners Compliance HelpLine at
http://www.partners.org/complianceline . If the e-mail was sent to you in error
but does not contain patient information, please contact the sender and properly
dispose of the e-mail.