Dear All,

 

we are running a project on brain morphometry in a clinical sample without brain injury.

For most patients, we have both:

• T1W isotropic 1mm post-gadolinium
• T2W TSE with 4mm axial slices

 

We would like to obtain high-resolution T1 images with SynthSR followed by standard voxel-based and surface-based processing in CAT12.

I am wondering which contrast is best suited for our purpose, also considering that our clinical sample has no brain injury and the only blood vessels are enhanced in post-gadolinium sequences.

 

I made some attempts on both sequences for a couple participants and segmented them with CAT12.

The overall image quality rating is almost identical. So is the estimate of total intracranial volume, with some differences in grey matter volume estimation (generally smaller in synthetized post-gado sequences vs synthetized T2) and CSF (generally bigger in synthetized post-gado). I haven't checked surface-based metrics.

 

I am quite new to the field, and I really appreciate your help!

 

Best,

Lorenzo

 

 

 

 

Lorenzo Diana, PhD

PostDoc

 

Advanced Imaging Research (AIR) Group

 

Swiss Paraplegic Research

Guido A. Zäch Strasse 4

6207 Nottwil, Switzerland