Dear Bruce, 

Thanks for you for your response. I am trying to  generate an average hippocampal volume and its correlation with HAM-D score in early and late onset depression (eod vs lod). One way I tried to do it was by binarizing and concatanating the hippocampal volumes and then run mri_glmfit. But, I am stuck at glm_fit and would be grateful if you can let me know how to proceed from here. How do I run the glm_fit between eod and lod patients? Secondly, after running glm_fit how do I calculate the significance from sig.mgh?

Appreciate all your help. 

Thanks and regards,

Sampada

On Sun, Jul 10, 2016 at 7:15 PM, Bruce Fischl <fischl@nmr.mgh.harvard.edu> wrote:
Hi Sampada

can you elaborate a bit? What are you trying to achieve? Do you want an
average hippocampus? Average maps of subfields? What hypothesis are you
trying to test? The individual subject data is not resampled to a common
coordinate system, so just averaging them as is won't produce anything
interested.

cheers
Bruce

On Sun, 10 Jul 2016, Dr
Sampada Sinha wrote:

> Dear freesurfer experts,
> Will you please let me know if it's possible to get one average mgz image
> file by concatenating the hippocampal volumes of different subjects using
> dev version? Since, I already have the hippocampal subfields mgz volume
> files, I intend to run the glmfit later on between two groups to get sig.mgh
> files.
>
> Thanks and regards?
>
> Sampada
>
>
> --
> Sampada
> Pre-doctoral student
> Department of Geriatric Mental Health (DGMH)
> King George Medical University
> Lucknow-226003
> India
>
>
>
>
>
>
>
>
>
>
>
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--
Sampada
Pre-doctoral student
Department of Geriatric Mental Health (DGMH)
King George Medical University
Lucknow-226003
India