You probably installed the Intel Mac binaries to run on your Silicon Mac with an M1, M2, or M3 arm64 chip. But not all Intel binaries will run on the newer arm64 Macs. If you want to run that command you will need to download and install the silicon Mac nightly freesurfer build.

To remove your current freesurfer install, you can try running the uninstall script from the command line under what you set FREESURFER_HOME to,

$ cd $FREESURFER_HOME

$ sudo bash uninstall.sh

Once you have removed your current freesurfer installation, you can download and try installing the arm64 pkg,

https://surfer.nmr.mgh.harvard.edu/pub/dist/freesurfer/dev/freesurfer-macOS-darwin_arm64-dev-20240805.pkg

Right click with the mouse on the .pkg file and select “Open with —> install.app (default)". Then follow the prompts in the installer windows.

On Aug 5, 2024, at 21:45, Yang, Yaozhi <yangyaozhi@ufl.edu> wrote:

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Hello FreeSurfer Developers,

I am trying to use easyreg from the paper--- A ready‑to‑use machine learning tool for symmetric multi‑modality registration of brain MRI and the paper says that I can use freesurfer to get the easyreg function. But after I download freesurfur in my macbook, and run mri_easyreg –-help on the terminal, I get the error saying that zsh : illegal hardware instruction mri_easyreg --help. So can you help me with that? How can I use easyreg method? Thank you very much!

Best,
Yaozhi
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