Hi Andrew,
I don't know how the sulc measure gets computed and what it means
exactly. Probably someone else can tell.
The longitudinal treatment is identical as for example thickness.
The slope (rate) is a fit into the data across time. So a negative
slope means a reduction in whatever is measured. Once you find out
what exactly that measurement describes, you'll know what a smaller
value of that measurements means. Sorry, I can't be of more help.
Best, Martin
On 02/21/2013 12:14 PM, O'Shea,Andrew
wrote:
Hello,
I was wondering if I could get some clarification regarding
the longitudinal measure of rate of change in sulci depth. In
our study we have a patient population that participated in an
intervention and a similar group of wait list controls. We
have scans for pre and post intervention timepoints. I have
ran the longitudinal analysis in QDEC looking at the thickness
change measures, however I was also interested in the sulc
measures. I was able to get the analysis to run with the new
measures long.sulc-rate etc. However I am having a hard time
conceptualizing the meaning of the results. Does a negative
rate change indicate either a deepening or a shallowing of the
sulci? Is the opposite the case for gyral regions? Any advice
would be greatly appreciated.
-Andrew
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Dr. Martin Reuter
Assistant in Neuroscience - Massachusetts General Hospital
Instructor in Neurology - Harvard Medical School
MGH / HMS / MIT
A.A.Martinos Center for Biomedical Imaging
149 Thirteenth Street, Suite 2301
Charlestown, MA 02129
Phone: +1-617-724-5652
Email:
mreuter@nmr.mgh.harvard.edu
reuter@mit.edu
Web : http://reuter.mit.edu