That is interesting and good to know. Thanks.

I am looking for a reference that provides validation metrics on the Van Leemput (2010) method as implemented in Freesurfer. To your knowledge, is there such a reference?

Best,

Joshua



On Fri, Jun 7, 2013 at 12:49 PM, Juan Eugenio Iglesias <iglesias@nmr.mgh.harvard.edu> wrote:
Koen, please correct me if I'm wrong, but I'd say the answer is no.
Since these tissue classes share the same Gaussian parameters, their
likelihood term is the same, and the posterior is fully determined by
the prior (i.e., the atlas).
/E



On Fri, 2013-06-07 at 12:42 -0700, Joshua Lee wrote:
> Thanks Bruce and Eugenio,
>
>  Suppose I had two identical images of a subject, but in one image I
> reduced the contrast of internal lamina while leaving the rest of the
> image intact...just removing internal intensity differences, but
> leaving the outer boundary contrast intact.
>
> Would the images result in very different subfield segmentations?
>
> Josh
>
>
> -
>
> Joshua Lee
>
> Graduate Student
> Center for Mind and Brain &
>
> Department of Psychology
>
> University of California, Davis
> 530.747.3805
>
>
> On Fri, Jun 7, 2013 at 12:33 PM, Bruce Fischl
> <fischl@nmr.mgh.harvard.edu> wrote:
>         Hi Josh
>
>         it depends on intensity differences if it can find them as
>         well as boundary/geometry.
>
>         cheers
>         Bruce
>
>
>
>         On Fri, 7 Jun 2013, Joshua Lee wrote:
>
>                 I'm trying to understand Leemput's subfield algorithm
>                 better as implemented
>                 in Freesurfer. Does the algorithm make use of
>                 intensity differences in the
>                 internal hippocampal lamina from the subject's T1
>                 image to warp meshes and
>                 assign subfield probabilities? Or does it depend only
>                 on outward boundaries
>                 of the hippocampus and probability priors to determine
>                 the inner boundaries
>                 between CAs and dentate gyrus?
>                 -
>                 Josh
>
>
>
>
>
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--
Juan Eugenio Iglesias, PhD
http://www.jeiglesias.com
iglesias@nmr.mgh.harvard.edu
Athinoula A. Martinos Center for Biomedical Imaging
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