Dear All,

I am sorry to post this message again. Since i am not able to find from the tutorial and archives what i need i am posting it. I want to compare cortical thickness values in each region from aparc.stats file between control and patients. I am wondering whether it is possible to compare all the regions given in aparc.stats file and give a map showing which of these regions are significantly between the two groups (like VBM the final p map will give you regions which are significantly different).

Do i need to create a separate contrast matrix for each and every regions (for eg one contrast for lh.cuneus,one for  lh.temporalpole etc) or like in VBM  studies you give a single contrast matrix and design matrix since you are testing the same hypothesis in different regions of the cortex.

I also would like to know whether i have to do multiple comparisions when i am testing for same hypothesis in different regions or not needed. In the tutorials i find mostly regression between thickness and demographic parameters so any suggestion or guidance to where i can find tutorial or materials related to my above questions.

Thanks

venkat

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