Appreciate it Dr Bruce. Do you have guidelines for smoothing MD? 

Dr Yendiki, I am trying to investigate whether cortical MD can be a marker of neurodegeneration. The idea is that during the early stages of a disease, cellular microstructure may breakdown before cortical thinning occurs. This results in "less" barriers against diffusion resulting in an increase of MD. 


On Friday, August 11, 2017, 5:49:40 PM GMT+1, Bruce Fischl <fischl@nmr.mgh.harvard.edu> wrote:


Hi Shane

you probably don't need cvs as it is more to extend the surface-based
registration to the entire volume. Here you just need the surface-based
registration I believe. Use mri_vol2surf to sample the FA onto the surface.
After that it is identical to a thickness study

cheers
Bruce



On Fri, 11 Aug 2017, Shane Schofield
wrote:

> Thanks Dr Yendiki. 
>
> I am more interested to compare MD in grey matter regions by putting the MD on the surface, and then do a glmfit type of comparisons. Is that OK? Would you recommend me
> to smooth the data after spatial normalisation? I have also used the mri_cvs_register as described on the tutorial.
>
>
> On Friday, August 11, 2017, 7:03:49 AM GMT+1, Shane Schofield <shane.schofield@yahoo.com> wrote:
>
>
> Hi DTI Experts,
>
> Is it sensible to do comparisons of MD on the cortex surface like a normal cortical thickness comparisons between group? If the answer is yes, are there recommended on
> smoothing ?
>
> DT_RECON has been completed in Freesurfer.
>
> Thank you.
>
>
>
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