Hi Pietro

ICV (or eTIV) is computed using Randy Buckner's method, so you can cite his paper. Correcting for whole brain volume is certainly a reasonable thing to do but note that then you are testing a somewhat different hypothesis (that local atrophy is faster than whole-brain atrophy, as opposed to whether atrophy exists at all)

cheers
Bruce

On Mon, 11 Jan 2016, pietro de rossi wrote:

Dear FreeSurfers,
I am editing a paper on subcortical volumes in deficit schizophrenia after
some reviewers' comments.
On of them suggested me to correct the volumes of subcortical structures for
whole brain volume instead of intracranial volume. In the reviewer's opinion
ICV  estimated by FreeSurfer 5.1 has a bad quality and is not reliable.
However,  neither the reviewer provides any evidence, nor I could find
any...
Is there any evidence for this?

Thanks in advance,

Pietro

--
Pietro De Rossi, MD
-------------------------------------
Sapienza Università di Roma, Facoltà di Medicina e Psicologia, Dipartimento
NESMOS (Neuroscienze, Salute Mentale, Organi di Senso), Ospedale
Sant'Andrea, Via di Grottarossa 1035-1039, 00189 Roma

NESMOS Department (Neurosciences, Mental Health and Sensory Functions),
School of Medicine and Psychology, Sapienza University, Sant’Andrea
Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy

Laboratorio di Neuropsichiatria, Dipartimento di Neurologia Clinica e
Comportamentale, IRCCS Fondazione Santa Lucia, via Ardeatina 306 - 00179
Roma

Tel. +39 (0)6 51501358

Fax +39 (0)6 90280774

web: http://www.neuropsichiatrialab.com

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