Hi Gregory,

If looking at longitudinal changes, I would use uncorrected ROI volumes.  You could consider including ICV as a covariate (for offset and slope interaction, to test if ICV has an effect on your slopes).

Best, Martin

In writing a paper of longitudinal changes in a large heterogeneous population with no group comparisons, what would be considered "more important" to include: absolute ROI volumes, or volumes corrected for ICV?

Using ICV corrected volumes makes sense when comparing groups, but when just describing population changes over time, for example a cross section of a population over a lifespan, is it better to use absolute volumes, corrected volumes, or both?

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