Dear FreeSurfer team,

1. We are attempting to compute the average cortical thickness for controls and persons with a neurological condition. In some cases, we’ve noticed that the pre- and post-central gyri have shifted in the anteroposterior direction so that the left and right gyri are not aligned. A similar phenomenon has been reported previously (https://www.mail-archive.com/freesurfer@nmr.mgh.harvard.edu/msg70316.html) and solved. However, we get the following error when attempting the previously proposed solution:

ERROR: Flag -nospherereg unrecognized

Are there any other solutions or suggestions for addressing this shift that may work for us?

2. Also, if we are interested in analyzing the cortical thickness of the entire hemispheres using the mri_glmfit-function and not comparing specific ROIs directly, does the correct parcellation/labelling of specific ROIs matter?

Kind regards,

Carl

FreeSurfer version: freesurfer-linux-centos7_x86_64-7.1.1-20200723-8b40551

Platform: CentOS Stream 8

Screenshot: please see attached