On 7/9/2021 11:44 AM, Ritobrato Datta wrote:

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Hi All,

I have the following data –

 

I have 205 subjects - each subject was imaged at 3 timepoints (baseline, followup 1 and followup 2)

The 205 subjects are split in two treatment arms with 100 subjects in the first one and 105 subjects in the second one.

 

For each timepoint, I have created FA maps in their native diffusion space. 

I have also extracted the mean FA maps for 187 ROIs using mri_segstats. 

For each timepoint, I have saved the results as a matrix (FA in 187 ROIs x 205 subjects) in a text file. 

So I have three files for the three timepoints. 

 

I have the age and cognitive score for each subject at each timepoint. And their gender. 

 

I want to answer the following questions –

 

1. Do the baseline FA correlate with the corresponding cognitive score at baseline ?

This is a straight forward group analysis, so see MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://surfer.nmr.mgh.harvard.edu/fswiki/FsgdExamples (maybe the Two Groups (1 Factor, Two Levels), One Covariate)

1. I am interested in testing whether the FA changed significantly across the different timepoints and does that relate to the change in the cognitive score

See MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://surfer.nmr.mgh.harvard.edu/fswiki/RepeatedMeasuresAnova

1. Is there an effect of treatment on this change in FA across time ?

Also see MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://surfer.nmr.mgh.harvard.edu/fswiki/RepeatedMeasuresAnova

 

Can you please suggest what programs in freesurfer will allow me to test these questions on both voxelwise and ROI wise ?

Many thanks for your help and guidance,

Regards

Rito

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