Hi Folks,<div>We have subjects with high lesion load which changes significantly over time. </div><div>I want to use FS functions to build a pipeline for comparing lesion changes in two time-points of the same-subject. </div>

<div>I am thinking of using the following steps; </div><div><br></div><div>1) Use mri_normalize to normalize the two time-points. </div><div>2) Use mri_robust_register to register two time-points of the same subject to half-way space. <br>

<div>3) Use mri_skull_strip</div><div>4) Use subtraction imaging or some other techniques to look for lesion changes. </div><div><br></div><div><br></div><div>My questions are: </div><div>1) I think I need mri_normalize since the output from mri_robust_register  is not intensity normalized ? </div>

<div>2) Instead of the first three steps, I could also do the following: </div><div> Run autorecon1 for both timepoints and then run mri_robust_register on the skull stripped images </div><div>Does it matter if we run mri_robust_register before or after skull stripping ? </div>

<div><br></div><div>Thanks</div><div>Mehul </div><div><br></div><div><br></div><div><br></div><div><br></div></div>