João,
Here is my opinion:
I have worked on resolutions distinct than 1mm3 isotropic and usually I
have no problem. What do you mean by false negatives in your cohort
study?
I think you should avoid seeding data with skull striped by other program
to the pipeline.
Best Regards,
PPJ
2008/10/3 Joao Pereira
<jmsp2@wbic.cam.ac.uk>
Hello,
I
have a couple of questions on which I would like to have your
opinion.
The first is the voxel resolution impact on cortical
thickness sensitivity.
I'm using 1.25 mm3 isotropic voxels, and I know
that FS interpolates scans
to 1mm - is it possible that the 1.25 mm
resolution hinders cortical
thickness measurements? I'm asking this
because I'm analysing an AD cohort
whose result seems full of false
negatives (I'm in the process of inspecting
the intermediate steps as
well - I just wanted to check if resolution was a
factor as
well).
I would also like to know if it is possible (and advisable) to
input already
optimally skull stripped and bias corrected brains into the
recon-all
pipeline. If that is possible, I would assume that I need to
bypass those
steps, and I would like to know which arguments to use in
recon-all in order
to do so.
Thank you very much for all your
help!
Best,
Joao
Pereira
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