Dear FreeSurfer community,

I would like to ask for your advice regarding the use of NextBrain with MRI datasets acquired at different resolutions and coverage.

 

Specifically, I have:

 

Would it be possible (and methodologically sound) to combine these two datasets within the NextBrain pipeline? In particular, I am interested in whether the high-resolution brainstem scan can be integrated with the whole-brain image to improve segmentation or analysis in that region.

If this approach is feasible, I would appreciate any recommendations on preprocessing steps (e.g., registration, resampling, or intensity normalization) to ensure compatibility between the two images.

 

Thank you very much for your help.

 

Best regards,