Yes, I extracted the mean thickness of the ROI label from each timepoint to use it as a continuous variable and study the correlation of whole brain thickness with this region, is this ok?
On Friday, 19 February 2016, Douglas N Greve <greve@nmr.mgh.harvard.edu> wrote:
Hmmm, I think I'm more confused. what do you mean by "mean thickness of ROI from longitudinal group comparison"? You are looking at how the thickness across cortex correlates with the mean thickness in your ROI?
On 02/18/2016 05:50 PM, amirhossein manzouri wrote:
I just wanted to clarify a bit more to see if makes more sense now ?
On Thursday, 18 February 2016, Douglas N Greve <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> wrote:
Hi Amirhossein, I can't tell from below if you have a question or not
On 02/18/2016 05:32 PM, amirhossein manzouri wrote:
Hi and thanks, tp1 is before and tp2 after treatment, and the
measurement is the mean thickness of ROI from longitudinal
group comparison, so we basically want to see effect of
treatment on cortico cortical correlation.
On Thursday, 18 February 2016, Douglas N Greve
<greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>
wrote:
so you want to test whether the cross-sectional slope changes
across time? That is unusual, but you can do it by
specifying two
classes in the FSGD file, one for each time point. Also
specify a
variable which is your measurement. Then create a contrast
0 0 1
-1. This will test whether the slopes change between "groups",
where a "group" is the given time point. This analysis
does not
make sense to me, but that is how to do it.
doug
On 02/18/2016 12:16 PM, amirhossein manzouri wrote:
Hi,
We would like to run paired t-test on longitudinal within
group data for correlation analysis of one measurement and
cortical thickness, not cortical thickness comparison
at the
respective time point .
I found the paired analysis and read that but in fact
we need
to see if correlation between our measure and CTH
differs from
time point one to time point 2. So the question will
does the
thickness and measure1 correlation differs between time
point1 and tp2?
Best regards,
Amirhossein Manzouri
-- Douglas N. Greve, Ph.D.
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-- Best regards,
Amirhossein Manzouri
-- Douglas N. Greve, Ph.D.
MGH-NMR Center
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--
Best regards,
Amirhossein Manzouri
--
Douglas N. Greve, Ph.D.
MGH-NMR Center
greve@nmr.mgh.harvard.edu
Phone Number: 617-724-2358
Fax: 617-726-7422
Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
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--
Best regards,
Amirhossein Manzouri