Hello!

I am trying to generate significance maps for a paired-difference analysis of cortical thickness using multiple pairs of siblings, and was wondering if there is a way to incorporate the family ID as a random effect/covariate in Freesurfer. Is it possible for the family ID for each sibling pair to be used as a categorical/discrete variable to then see the effect of family on cortical thickness in addition to the main effects we are looking at? Any guidance would be greatly appreciated!

Best,
Casey

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Casey Hopkinson

Clinical Research Coordinator
Brain Genomics Laboratory
Division of Psychiatric Neuroimaging
Massachusetts General Hospital
149 13th Street, Charlestown, MA, 02129
(p) 617.643.3215