Dear Experts,

I was wondering if you could possibly help me with a reviewer-related question:

We conducted a between-group-analysis estimating the interaction between cortical thickness and age.

 In summary, we wanted to investigate whether the interaction between cortical thickness and age is stronger for one group relative to another (using a DODS design).

We cluster-corrected our results using a Monte Carlo cluster correction of p<0.01 and attained significant group differences for several areas over the left and right hemisphere.

One of the reviewer commented that although group differences were estimated for each hemisphere separately, they ought to have been cluster-corrected for both hemispheres.

Would you be able to tell me whether or not cluster-correcting for both hemispheres is a necessity, or help me understand the possible implications of not having cluster-corrected for both hemispheres?

Very Best Regards,

Catherine