Dear Martin，

Thank you for your reply. I used a paired analysis to do "two groups two times data of the longitudinal analysis".

But unfortunately, I did not make the results, and I use “mri_glmfit-sim” to find 0 vertices in mask.

My files are as follows.

Fsgd 1: (pairs.fsgd)

GroupDescriptorFile 1

Class Sub

Class Con

Input sub01_MR1 Sub

Input sub01_MR2 Sub

Input con01_MR1 Con

Input con01_MR2 Con

...

Fsgd 2: (paired-diff.fsgd)

GroupDescriptorFile 1

Class Sub

Class Con

Input sub01pair Sub

Input con01pair Con

...

mean.mtx: 1 -1

Are they correct in my Paired analysis? And I am trying LME now.

However, I see other people in the mailing list of the questions and replys, I realize that I may be wrong.

My two groups of two time are the experimental group (bs) and the placebo group (placebo).

I want to do “the crossover analysis” Just like:(postbs-prebs) - (postplacebo-preplacebo)

Should not I use longitudinal analysis for these two groups? What kind of analysis do I need to do?

Please tell me where I should look in the wiki.

Looking forward to reply, and thanks very much.

Kind regards,

Livia