Hi Doug,

Sorry for not elaborating in my previous email.

Voxel lesion symptom mapping (VLSM) is a method to calculate symptom localization by estimating statistical relationships between damage to specific brain regions (it could be stroke lesion, tumor lesion or TBI lesion etc.) and resulting deficits (e.g., MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724038/ and MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://academic.oup.com/brain/article/137/9/2532/2848278). This method can guide the development of targeted interventions and rehabilitation strategies aimed at improving symptoms by targeting specific brain regions (or networks, if we use network lesion symptom mapping: MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to be https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724189/).

On Fri, Feb 23, 2024 at 10:27 AM Douglas N. Greve <dgreve@mgh.harvard.edu> wrote:

Sorry, don't know what VLSM is. Can you elaborate?

On 2/6/2024 3:19 PM, Martin Juneja wrote:
External Email - Use Caution

Dear FreeSurfer community and experts,

I would greatly appreciate any help/response with the following.

Thanks.

---------- Forwarded message ---------
From: Martin Juneja <mj70481@gmail.com>
Date: Wed, Jan 31, 2024 at 7:51 PM
Subject: Vertex / voxel lesion symptom mapping
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>

Greetings FreeSurfer community,

I was just wondering if it's possible to perform vertex/voxel lesion symptom mapping (VLSM) using FreeSurfer? In other words, I would like to assess the impact of lesion topography (of course, heterogenous locations across patients) on neurocognitive function in brain tumor patients.

I would greatly appreciate any help/response.

Thanks!
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