Hi Vittal,

Sorry, I can only help on the public freesurfer list, so I suggest moving the discussion back to there.

Best,

Kersten

Am 27.11.2020 um 18:21 schrieb vittal korann <vittalkorann@gmail.com>:

Hi Kersten

Thank you for kind response.

I think we need to talk about the design matrix X first (sorry, I did not look at your xlsx file; I think it's probably better to send simple csv files if at all).
I attached longitudinal data in csv format. 

Besides the covariates that you mention, the matrix needs to contain an intercept, a variable for ?time?, a variable for ?group? (assuming you have a control group also), and a group-by-time interaction term in order to asses differential change over time (again, if you have a control group).
I do not have a control group. Right now I have only schizophrenia patients who underwent 2 scans: first is baseline and second one is after 3 months of yoga therapy. Wish to know the how can I proceed with my availabe data.

Just to make sure: ?age? should be ?age at baseline? (i.e. constant across time per subject), otherwise it will be confounded with time.

Yes, I used same across the study.

Could you review (and possibly adapt) your design matrix X with respect to which columns it contains, and write it in the reply?

I tried but couldn't get there. 

Looking forward to your response.

Thanks,

Vittal

<longitudinal_data.csv>

--
Kersten Diers
Image Analysis Group (AG Reuter)
German Center for Neurodegenerative Diseases (DZNE) 
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