Hello All,

We are trying to obtain an accurate measurement of the total WM volume (cerebral WM + WM hypointensities) in a group of patients with multiple sclerosis.

As per Bruce’s suggestion, we are using mris_wm_volume that should give more accurate measures than aseg.stats.

When looking at our data we have noticed that within the WM surface (yellow line) there are many voxels labeled as ?h-Cerebral-Cortex, and some juxtacortical lesions labeled as None

Upon manual editing of these mislabeled voxels on the aseg.mgz (i.e. relabeling them as WM), we have noticed that WM volume actually change.

Since mris_wm_volume computes the WM volume using the WM surface and subtracting all non WM structures, we were wondering if there is any way to capture and correct for all these mislabeled voxels in a more automated manner (i.e. automatically considering them as WM instead of subtracting them from WM).

In this way it should be possible to get more accurate measures of WM volumes as well as save a lot of time in manual editing.

Thanks a lot in advance,

Antonio

Antonio Gallo, MD

NIB-NINDS-NIH

10 Center Drive

Building 10, Room 5C203B

Bethesda, MD, 20892 - USA

ph #: 001-301-496.7368

fax #: 001-301-402.0373

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