I have a question regarding grey matter thickness map and signal to noise ratio. Does smoothing of the map increase signal to noise during surface based cortical thickness analyses? if yes or no, why? This question was asked by a reviewer in one of our manuscript because he/she thinks that one of the reasons to perform smoothing is to comply with random field theory hypotheses, when controlling for multiple testing. 

We did apply multiple comparison corrections using monte carlo simulation with cluster threshold of 2, 5000 iterations, and bonferroni. 

Thanks alot. 

best,

Paul