The two templates were created by using the same 40 subjects as a training data set as is used by Freesurfer. The volumes were registered to a common space by an iterative framework in which you create a mean, register individuals to it and then re-create the mean. We then reconned the final mean. The MNI equivalent was created by moving the mean to the MNI152 space before running recon.

From: freesurfer-bounces@nmr.mgh.harvard.edu <freesurfer-bounces@nmr.mgh.harvard.edu> on behalf of バキット・ムダシル <m-bakhit@fmu.ac.jp>
Sent: Wednesday, April 14, 2021 6:55 AM
To: Freesurfer support list <Freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] The cvs_avg35

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Hi,
I was looking for any document describes how the cvs_avg35 and cvs_avg35_inMNI152 were made? Can you please send me a link or give me a brief about it please? I searched in the freesurfer wiki and here in the freesurfer folder but no success.
Also, I found from literature that the fsaverage was made from a data of 40 subjects that includes 10 cases of Alzheimer disease. Can I ask what was the reason to include those 10 cases to create this template?

Thanks

Mudathir

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