Dear all,

We have been working quite extensively with Freesurfer over the years. We are now starting to collect a new large cohort and we are about to decide which T1-weighted sequence to use, MPRAGE or MP2RAGE  (Siemens 3T Prisma, headcoil 20 Chanel).  When we visually inspect the images we think there is a better contrast between GM and WM in the MP2RAGE over the traditional MPRAGE sequence. Both sequences seem to produce good Freesurfer output, but the cortex tend to be a bit thinner with MP2RAGE, possibly due to the better contrast, but we can of course not be sure of this. Freesurfer have always produced nice results with the MPRAGE sequence and the MPRAGE flag seems to work well. Do you think this flag will work as well on MP2RAGE? Of course it is difficult to say but we wonder if you have any opinion on which sequence to use?

Thank you very much,

Best regards

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