I think so. Just make sure you don't try to draw conclusions from the ROI or area around it.

On 2/19/16 2:02 AM, amirhossein manzouri wrote:

Yes, I extracted the mean thickness of the ROI label from each timepoint to use it as a continuous variable and study the correlation of whole brain thickness with this region, is this ok?

On Friday, 19 February 2016, Douglas N Greve <greve@nmr.mgh.harvard.edu> wrote:

Hmmm, I think I'm more confused. what do you mean by "mean thickness of ROI  from longitudinal group comparison"? You are looking at how the thickness across cortex correlates with the mean thickness in your ROI?

On 02/18/2016 05:50 PM, amirhossein manzouri wrote:

I just wanted to clarify a bit more to see if makes more sense now ?

On Thursday, 18 February 2016, Douglas N Greve <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> wrote:

    Hi Amirhossein,  I can't tell from below if you have a question or not

    On 02/18/2016 05:32 PM, amirhossein manzouri wrote:

        Hi and thanks, tp1 is before and tp2 after treatment, and the
        measurement is the mean thickness of ROI  from longitudinal
        group comparison, so we basically want to see effect of
        treatment on cortico cortical correlation.

        On Thursday, 18 February 2016, Douglas N Greve
        <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>
        wrote:

            so you want to test whether the cross-sectional slope changes
            across time? That is unusual, but you can do it by
        specifying two
            classes in the FSGD file, one for each time point. Also
        specify a
            variable which is your measurement. Then create a contrast
        0 0 1
            -1. This will test whether the slopes change between "groups",
            where a "group" is the given time point. This analysis
        does not
            make sense to me, but that is how to do it.
            doug

            On 02/18/2016 12:16 PM, amirhossein manzouri wrote:

                Hi,
                We would like to run paired t-test on longitudinal within
                group data for correlation analysis of one measurement and
                cortical thickness, not cortical thickness comparison
        at the
                respective time point .
                I found the paired analysis and read that but in fact
        we need
                to see if correlation between our measure and CTH
        differs from
                time point one to time point 2. So the question will
        does the
                thickness  and measure1 correlation differs between time
                point1 and tp2?



                Best regards,
                Amirhossein Manzouri



            --     Douglas N. Greve, Ph.D.
            MGH-NMR Center
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        --         Best regards,
        Amirhossein Manzouri




    --     Douglas N. Greve, Ph.D.
    MGH-NMR Center
    greve@nmr.mgh.harvard.edu
    Phone Number: 617-724-2358
    Fax: 617-726-7422

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--
Best regards,
Amirhossein Manzouri

--
Douglas N. Greve, Ph.D.
MGH-NMR Center
greve@nmr.mgh.harvard.edu
Phone Number: 617-724-2358
Fax: 617-726-7422

Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
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--

Best regards,
Amirhossein Manzouri