Hi Bruce,

Thanks for your help!

But - would you recommend a longitudinal analysis even though i have quite many movement artefacts and bad scans - instead of just avoid using the worst picture? At the moment I'm making a cross-sectional study. I would also like to make an investigation of OFC grey matter thickness in the two groups; on and off medication (using freesurfer).

Is Martin Reuther on vacation at the moment?

Best, Silas

Date: Fri, 25 Jul 2014 09:45:16 -0400
From: fischl@nmr.mgh.harvard.edu
To: freesurfer@nmr.mgh.harvard.edu
Subject: Re: [Freesurfer] Freesurfer ROI analysis

Hi Silas
 
I'll leave the movement question for Martin Reuter who has been 
investigating this extensively.
 
For your other question, one of the central focuses of our recent research 
has been in improving the sensitivity and reliability of longiudinal 
analyses like these, so it is definitely a major strength of ours.
 
cheers
Bruce
 
On Fri, 25 Jul 2014, Silas wrote:
 
> Hi Freesurfer,
> I'm currently making a structural analysis on about 60 Parkinson's Disease
> patients using freesurfer - and i would like to make a ROI analysis. I have
> two MR pictures of each subject; a picture where the patients are on
> medication and an off medication picture (the medication is levodopa:
> Precursor to catecholamines e.g. dopamin). I would like to investigate the
> morphological differences in specific areas of the brain such as Nucleus
> Accumbens bilat., Orbitofrontal cortex bilat. and Anterior Cingulate Cortex.
> How would you consider freesurfer's strength in investigating differences in
> such specific areas in the brain?
> 
> I have another question regarding movement artefacts. In a structural
> analysis would you remove pictures with movement artefacts if the
> segmentation after manual editing seems alright?
> 
> Best,
> Silas
> 
>

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