Hi Freesurfer Experts,

 

Just to make it sure i have a question about correcting for cranial size.

 

I compared two groups, 100 patients versus 50 Controls. I entered a discrete variable 'groups' (Patients: 1 and controls:2) in qdec. For cortical thickness difference between these groups, do i have to control for total intracranial volume? ICV (intra cranial volume is output from aseg2tables) or controlling for another variable which estimate total brain volume, like total gray matter or supra tentorial volume?

 

In my correlation analyses, relating cognitive peformance and cortical thickness within the patient group. Do i have to control for ICV or Total gray matter? besides the variable age, gender and education.

 

I think only volume differences between groups need controlling for ICV, is that correct?

 

And in my correlation analyses, relating cognitive performance ato  subcortical volume within the patient group. Do i have to control for ICV or Total gray matter? besides the variables age, gender and education.

 

Do you have a reference to a methodological paper, which descibes different (anatomical) nuisance factors and their influence on the data? Is there a automated correction for brain size in the cortical and subcortical freesurfer stream (step of recon -all command)?

 

Many Thanks,

Stan