I have not looked at enough to really know. You may get a small boost in power, but it will probably only help if the effects you are looking at are right on the edge of significance.

Dear FreeSurfer team,

I'm making a surface based group analysis of 40 multiple sclerosis subjects using FreeSurfer tools. 

What are the advantages of building your own fsaverage (make_average_subject) instead of using the premade fsaverage? Would you in general recommend this? What is the pro's and con's of building your own fsaverage?

All the best,

Silas

I searched the mailing stream and found this answer:

'make_average_subject script, but as Doug implies you probably don't need to. Our warp is 
high-enough dimensional that you rarely need to build average subjects from 
your own population'

_______________________________________________
Freesurfer mailing list
Freesurfer@nmr.mgh.harvard.edu
https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer