Dear Doug and Jorge,
Thank you very much for your help.
I found another message in the list (https://mail.nmr.mgh.harvard.edu/pipermail//freesurfer/2013-November/034649.html) in which you suggested a way of using MC in mri_glmfit-sim by creating “fake files”, which would not be read by the script. In this case, only the simulation would be run, and not the full statistics. The command would be something like this:
- mri_glmfit-sim --glmdir $SUBJECTS_DIR --sim mc-full 5 2 teste --sim-sign abs
I created a “fake” mri_glmfit.log, fwhm.dat and mask.mgh files as suggested by the older post. This would be fine, I believe, if only sig.mgh is read by the script.
However, I get this message after running the command:

[server:Long-T0-T2-Posproc/Vertex/Sch] pedrogomesrosa% mri_glmfit-sim --glmdir $SUBJECTS_DIR --sim mc-full 5 2 teste --sim-sign abs

if: Expression Syntax.


Is it possible to do what I am trying to do? Does the residual errors at each location included in the sig.mgh, and, if necessary, how to compute it into image FWHM?

Regards,

Pedro Rosa.

On Friday, March 28, 2014 at 2:38 PM, Douglas N Greve wrote:

Jorge, do you output the FWHM?
doug

On 03/27/2014 03:14 PM, jorge luis wrote:
Hi Pedro

Sorry, right now the only multiple comparisons corrections implemented
in lme are the original Benjamini and Hochberg (1995) FDR procedure
(lme_mass_FDR) and a more recent and powerful two-stage FDR procedure
(lme_mass_FDR2):

Benjamini, Y., Krieger, A.M., Yekutieli, D. (2006). Adaptive linear
step-up procedures that control the false discovery rate. Biometrika,
93, 491-507.

In my experience, this procedure is as powerful to detect effects in
neuroimage data as alternative corrections with strong control of the
family-wise error rate (FWE). However it would be great if we could
use an implementation of any multiple comparisons correction with
strong control of the FWE (MC, RFT, ect...) for lme (FDR procedures
only provide weak control). The residual errors at each location
required to compute an estimate of the image FWHM can be obtained from
the lme output. But an actual FWHM estimate is not currently saved.

Best
-Jorge


El Martes 25 de marzo de 2014 8:15, Pedro Rosa

Dear Doug,
Thank you very much!
I will try what you suggested, although I am not sure if Jorge's
stream outputs the FMHM, or if I would need to run the statistics
from the beggining using in the terminal, and not in MatLab.
Do you think Jorge could comment on this issue?
Regards,
Pedro Rosa.

On Mar 24, 2014, at 12:44 PM, Douglas Greve
<greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> wrote:


In theory, it should be possible. I have not used Jorge's stream,
so I
don't know that much about it. Does it save an estimate of the
FWHM? If
so, then you can run mri_surfcluster passing it the p-value (ie,
-log10(p)) map, the FWHM, the mask, and a voxel-wise threshold.
This is
what mri_glmfit-sim does, so you might check that script for
mri_surfcluster command line options

doug


> On 3/22/14 11:03 PM, Pedro Rosa wrote:
> Dear list,
> I ran the recon-all and the Freesurfer 5.1 longitudinal pipeline
in a structural MRI dataset and I would like to use Monte Carlo as
the method for correction for multiple comparisons. However, the
longitudinal LME tutorial includes only FDR correction
(lme_mass_FDR2).
> Is it possible to use Monte Carlo correction for longitudinal
data? Can I input the outputs from MatLab (fstats =
lme_mass_F(?h,CM): stats.F / pval / sgn / df) into mri_glmfit and
then run Monte Carlo?
> If not, do you have any other suggestions of how I use Monte
Carlo in longitudinal analyses?
> Thanks in advance,

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