Hi.

My question is about dealing with multiple sclerosis lesions in white matter.

I have previously worked with this sample in SPM8, and I have a binary mask for each subject with the white matter lesions marked.

Instead of painting manually each lesion with the freesurfer interface, could I provide to the freesurfer the T1 images with the lesions painted with another program? (exactly, with the IMcalc of SPM, to set lesion values of each T1 image to a standard WM value according to the binary mask). Is this procedure correct? What value should I provide to this lesions?

Thanks.