Dear Tracula Team,

i noticed that TRACULA uses fsl's flirt with "mutualinfo" as cost function to register the anatomical individual T1 brain (brain_anat.nii.gz) to the MNI152 space T1 template (MNI152_T1_1mm_brain.nii.gz), i.e. for an intramodal registration.

I was wondering why "mutualinfo" (which is often used for intermodal registrations) is also used for a an intramodal registration in TRACULA'S implementation rather than e.g. least squares or correlation ratio, the latter being the fsl default.

Is "mutualinfo" preferable not only for intermodal (e.g., b0 -> t1) but also for intramodal t1->t1 registrations for your purpose ? - I am just curious to know :)

kind regards,
andi