What I mean is to process every subject only once and not twice (with flipped images, if that is what you did?).

Then run xhemi analysis on the subject-level. Invert the sign of the left-right difference depending on which is the diseased hemi. Then do a regular analysis on that. Nothing paired.

On 30. Aug 2018, at 18:29, Wang, Xiaoyu <xwang13@pennstatehealth.psu.edu> wrote:

Thanks Martin,

Yes, I did mean to have the right hemisphere added to the left hemisphere as a new time point.

Can you explain on what you mean by run every subject only once?
Do you mean to run xhemi for all of the subjects and then run a paired analysis?

Xiaoyu

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