On 7/11/2018 11:37 AM, John Anderson wrote:

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Dear Freesurfer experts,
I have two groups of subjects (healthy and patients). The patients have different degrees of atrophy. Looking into the individual scans, the subjects are largely different in the space between the sulcuses and the size of ventricles. My questions are:
1. Is there any way to correct for these differences in the surface based analysis?
What kind of correction? I'm not sure I understand what the problem is.
2. Including eTIV covariate does it help in this case?
No, since the skull does not change with atrophy
3. Does the resampling to "fsaverage" overcome the challenge of these differences between the subjects?
See #1

I appreciate any advice,
John

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