Dear experts,

Could you please help me in resolving following issue?

Thanks.

---------- Forwarded message ---------
From: Martin Juneja <mj70481@gmail.com>
Date: Wed, Nov 28, 2018 at 2:23 PM
Subject: Overall maxima is high and still no significant cluster
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>

Hi FS experts,

I am estimating the group-behavioral thickness interaction using contrast 2 FSGD file: https://surfer.nmr.mgh.harvard.edu/fswiki/Fsgdf2G2V at CFT < 0.01 and CWT < 0.05 at FWHM of 12 mm.

I do not find any significant clusters and my output summary text file looks like the following. This file shows that overall maxima is 4.58212 (which corresponds to p < 0.0001 because -log (0.0001) = 4, so I am just wondering despite the fact that maxima is > 4, why I do not see this cluster in the summary/output *.mgh file?

I would really appreciate any clarification and tips to modify my input thresholds so that I do not miss any significant findings here.

Thanks.

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# SearchSpace_mm2 76467.1

# SearchSpace_vtx 149953

# Bonferroni 2

# Minimum Threshold 2

# Maximum Threshold infinity

# Threshold Sign abs

# AdjustThreshWhenOneTail 1

# CW PValue Threshold: 0.05

# Area Threshold 0 mm^2

# CSD thresh 2.000000

# CSD nreps 10000

# CSD simtype null-z

# CSD contrast NA

# CSD confint 90.000000

# Overall max 4.58212 at vertex 10608

# Overall min -2.84277 at vertex 75476

# NClusters 0

# FixMNI = 0

# ClusterNo Max VtxMax Size(mm^2) MNIX MNIY MNIZ CWP CWPLow CWPHi NVtxs WghtVtx Annot