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They just described this regarding the ICC in their methods section: "For the present study, intrinsic cortical curvature was calculated using Gaussian curvature calculations in the following regions of interest from both the left (LH) and right (RH) hemispheres: the caudal anterior cingulate cortex (henceforth “ACC”), the rostral middle frontal cortex (henceforth “DLPFC”), the superior parietal region (henceforth “parietal cortex”), and the superior temporal region (henceforth “temporal cortex”). The regions of ICC quantification were chosen from their delineation atlas, the Desikan-Killiany cortical atlas (Desikan et al., 2006), for their approximation to regions of observed glutamatergic dysregulation (Iwata et al., 2019; Shah et al., 2020b) and structural decline (Anderson et al., 2015; Bodnar et al., 2010; Fan et al., 2023; Wannan et al., 2019) in available literature."

Thanks,
Vittal



On Wed, Jul 23, 2025 at 3:50 PM <freesurfer-request@nmr.mgh.harvard.edu> wrote:
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Today's Topics:

   1. Inquiry Regarding Intrinsic Cortical Curvature (ICC) Calculation in FreeSurfer
      (vittal korann)
   2. Re: Inquiry Regarding Intrinsic Cortical Curvature (ICC) Calculation in FreeSurfer
      (Fischl, Bruce R.,PHD)


----------------------------------------------------------------------

Message: 1
Date: Wed, 23 Jul 2025 15:44:14 -0400
From: vittal korann <vittalkorann@gmail.com>
Subject: [Freesurfer] Inquiry Regarding Intrinsic Cortical Curvature
        (ICC) Calculation in FreeSurfer
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Message-ID:
        <CACyMoT3Vps-CC9G=mFeHvNJJCh9LfhSVbVNskAwfi8H-6np7ow@mail.gmail.com>
Content-Type: multipart/alternative;
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        External Email - Use Caution       

Dear FreeSurfer Team,

I’m currently working on a project involving cortical morphology and am
particularly interested in calculating Intrinsic Cortical Curvature (ICC)
using FreeSurfer.

I came across a recent publication (
https://secure-web.cisco.com/1oL8IZPRfQ5o5UDqVHfF8rU4SLPTHeXEdS4OHOftgKkxaXnXs_JcjgvX9Pe6OjBAkg-u6fxy2Cx-D41wHlEOMEUS_Tk4d7v7Qx3Likv_shYeRtBnydcyfIwu-HBDJKzLVej16EUEX-HNd8WGxTf7Ghvp8It6AivG6yuekw2Fms7MQqM2usIj69bSUOCgHXEJVNndJssFPN8-cnhlMpo8F3l1h9DmbUW45d2fUw_JIGOzVK4lBhAakU7epXVGW1WTQ80Aykb2L7XDlPgosOWOufDrB0xiUu0Tc0OmbMxmp5guJBLGRXwomIYU_9p_795vNmXJLXjWb0vLGetc7x5nWPw/https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F38761434%2F) that utilized ICC in their
statistical analysis. I’d like to clarify a couple of points regarding how
ICC is derived within the FreeSurfer framework:

1. Is Gaussian curvature as computed by FreeSurfer considered equivalent to
ICC?

2. If not, are there additional steps or specific tools required to compute
ICC beyond the standard curvature outputs (e.g., via mris_curvature or
mris_curvature_stats)?

Any guidance or documentation you could share would be greatly appreciated.
I’m aiming to ensure methodological consistency with published work and
would be grateful for your insights.

Thank you for your time and support.

With regards,
Vittal
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Message: 2
Date: Wed, 23 Jul 2025 19:49:47 +0000
From: "Fischl, Bruce R.,PHD" <BFISCHL@mgh.harvard.edu>
Subject: [Freesurfer] Re: Inquiry Regarding Intrinsic Cortical
        Curvature (ICC) Calculation in FreeSurfer
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Message-ID:  <DM5PR04MB1261427D8F3DADE6FD8C37DEEF5FA@DM5PR04MB1261.nam
        prd04.prod.outlook.com>
Content-Type: multipart/alternative;    boundary="_000_DM5PR04MB126142
        7D8F3DADE6FD8C37DEEF5FADM5PR04MB1261namp_"

Sorry, what is their definition of ICC? Certainly Gaussian Curvature is an intrinsic geometric measure of curvature, but not sure if that is what they mean

From: vittal korann <vittalkorann@gmail.com>
Sent: Wednesday, July 23, 2025 3:44 PM
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] Inquiry Regarding Intrinsic Cortical Curvature (ICC) Calculation in FreeSurfer


        External Email - Use Caution
Dear FreeSurfer Team,

I’m currently working on a project involving cortical morphology and am particularly interested in calculating Intrinsic Cortical Curvature (ICC) using FreeSurfer.

I came across a recent publication (https://pubmed.ncbi.nlm.nih.gov/38761434/<https://secure-web.cisco.com/1oL8IZPRfQ5o5UDqVHfF8rU4SLPTHeXEdS4OHOftgKkxaXnXs_JcjgvX9Pe6OjBAkg-u6fxy2Cx-D41wHlEOMEUS_Tk4d7v7Qx3Likv_shYeRtBnydcyfIwu-HBDJKzLVej16EUEX-HNd8WGxTf7Ghvp8It6AivG6yuekw2Fms7MQqM2usIj69bSUOCgHXEJVNndJssFPN8-cnhlMpo8F3l1h9DmbUW45d2fUw_JIGOzVK4lBhAakU7epXVGW1WTQ80Aykb2L7XDlPgosOWOufDrB0xiUu0Tc0OmbMxmp5guJBLGRXwomIYU_9p_795vNmXJLXjWb0vLGetc7x5nWPw/https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F38761434%2F>) that utilized ICC in their statistical analysis. I’d like to clarify a couple of points regarding how ICC is derived within the FreeSurfer framework:

1. Is Gaussian curvature as computed by FreeSurfer considered equivalent to ICC?

2. If not, are there additional steps or specific tools required to compute ICC beyond the standard curvature outputs (e.g., via mris_curvature or mris_curvature_stats)?

Any guidance or documentation you could share would be greatly appreciated. I’m aiming to ensure methodological consistency with published work and would be grateful for your insights.

Thank you for your time and support.

With regards,
Vittal

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