Hi Shane,

not really. You can of course run images through the stream. You will get measurements, but you will not know how much of that is caused by the scanner or by disease (or drug,etc). If you have 2 groups, you could model the scanner as a co-var, but there could be a group scanner interaction and you have no way to test that.

You could scan a few people on both scanners to estimate scanner effects etc. If those are smaller than what you find above, you can argue that some of that could be real.

Best, Martin

Am 18.12.2017 um 16:49 schrieb Shane Schofield:

Hi Freesurfer Team,

I try to calculate a within-subject decrease in cortical thickness over 2 years, but the MRI scanner was changed during the project. Is it still possible to do that using the longitudinal stream in Freesurfer?

Thanks.

Best Wishes,

Shane
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