Dear Members,
I am using mri_glmfit for the first time with the .fsgd file below, however, I am receiving the following error: ERROR: matrix is ill-conditioned or badly scaled, condno = 1e+08
--------------------------------
Possible problem with experimental design:
Check for duplicate entries and/or lack of range of
continuous variables within a class.
I have also pasted the design matrix below as I cannot figure out what is wrong with it. I would really appreciate if anyone could help me this issue. Also note that I am running this for just a subset of my total data set as a test before I run it on my full data set.
Thank you very much for your help,
Sinead
GroupDescriptorFile 1
Title MIR137
Class TGFemale
Class TGMale
Class TTFemale
Class TTMale
Variables Age
Input CON3140/001 TGFemale 37
Input CON3891/001 TTFemale 33
Input CON4664/001 TTFemale 40
Input CON5591/001 TTMale 41
Input CON7009/001 TGMale 21
Input CON7024/001 TTMale 59
Input CON7038/001 TTMale 56
Input CON7050/001 TTMale 30
Input CON7054/001 TTMale 43
Input CON7055/001 TTMale 43
Input CON7072/001 TTFemale 41
Input CON7082/001 TTFemale 29
Input CON7087/001 TTFemale 23
Input CON7090/001 TGFemale 59
Input CON7092/001 TTFemale 21
Input CON9004/001 TGFemale 28
Input CON9009/001 TTMale 42
Input CON9040/001 TTMale 56
Input CON9064/001 TTMale 55
Input CON9069/001 TGFemale 54
Input CON9070/001 TTFemale 55
Input CON9081/001 TTFemale 50
Input CON9091/001 TTMale 27
Input CON9093/001 TTMale 54
DefaultVariable Age
Normalized matrix condition is 1e+08
Design matrix ------------------
1.000 0.000 0.000 0.000 37.000 0.000 0.000 0.000;
0.000 0.000 1.000 0.000 0.000 0.000 33.000 0.000;
0.000 0.000 1.000 0.000 0.000 0.000 40.000 0.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 41.000;
0.000 1.000 0.000 0.000 0.000 21.000 0.000 0.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 59.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 56.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 30.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 43.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 43.000;
0.000 0.000 1.000 0.000 0.000 0.000 41.000 0.000;
0.000 0.000 1.000 0.000 0.000 0.000 29.000 0.000;
0.000 0.000 1.000 0.000 0.000 0.000 23.000 0.000;
1.000 0.000 0.000 0.000 59.000 0.000 0.000 0.000;
0.000 0.000 1.000 0.000 0.000 0.000 21.000 0.000;
1.000 0.000 0.000 0.000 28.000 0.000 0.000 0.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 42.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 56.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 55.000;
1.000 0.000 0.000 0.000 54.000 0.000 0.000 0.000;
0.000 0.000 1.000 0.000 0.000 0.000 55.000 0.000;
0.000 0.000 1.000 0.000 0.000 0.000 50.000 0.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 27.000;
0.000 0.000 0.000 1.000 0.000 0.000 0.000 54.000;
--
Sinead Kelly
Neuropsychiatric Genetics Group
Trinity Centre
St. James's Hospital
Dublin 8