PS: the code is freely available (https://github.com/acasamitjana/uslr) it’s just that it’s not integrated into FreeSurfer. Actually, if you try it, Adrià and I would love your feedback 😊

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Juan Eugenio Iglesias

http://www.jeiglesias.com

From: Iglesias Gonzalez, Juan E. <JIGLESIASGONZALEZ@mgh.harvard.edu>
Date: Tuesday, July 1, 2025 at 8:18 PM
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Subject: Re: Measuring longitudinal changes in brain volume using SynthSeg

Hi Marco,

We’ve built a wrapper method around it. We just got it published but haven’t found the time to make it easily usable (also, the first author is on leave…). But we’ll get there 😊

https://www.sciencedirect.com/science/article/pii/S1361841525002099

Cheers,

/Eugenio

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Juan Eugenio Iglesias

http://www.jeiglesias.com

From: Marco Ganzetti <marco.ganzetti@biogen.com>
Date: Tuesday, July 1, 2025 at 11:31 AM
To: freesurfer@nmr.mgh.harvard.edu <freesurfer@nmr.mgh.harvard.edu>
Subject: [Freesurfer] Measuring longitudinal changes in brain volume using SynthSeg

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Does SynthSeg offer any functionality for estimating longitudinal changes in segmented brain volumes beyond simply subtracting values from two time points?

Marco