Thank you very much for your response. 

Out of curiosity, does someone know why the ADNI protocol has an anisotropic voxel resolution?

I was wondering if it had to do with the increased SNR being more beneficial for accurate segmentation than the gain in resolution from a 1mm isotropic voxel... or, perhaps it is meant to speed things up and and cover the whole brain a bit quicker?

Cheers,

Antonio






On Wednesday, November 19, 2014, Antonio Algaze Beato <antonio.algaze@upr.edu> wrote:
Dear group,

I am new to FS and the ADNI protocol, thus my question: is it ok to have a slice thickness of 1.2 mm and in-plane resolution of 1.05 mm for cortical segmentation and brain volume analyses? This seems to be a sequence suggested on the FreeSurferWiki (I am using a GE750 3T). 

Doesn't the anisotropic resolution introduce a bias?

Thanks a lot!




--
Antonio Algaze, PhD
University of Puerto Rico
Physics, UPR-Bayamón
Radiology, UPR-School of Medicine