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Hello PetSurfer Developers

On the tutorial page, I do not understand this part:

--km-hb 11 12 13 50 51 52 specifies the ROIs to use as the high-binding region if using MRTM2. This creates km.hb.tac.nii.gz with the value for the high-binding region for each time point.

What exactly is a high-binding region and how do these inputs affect the rest of the estimation? If I do not know what the high binding regions for a tracer are, may I leave this blank?

Thank you.