Hi Letitia

I wouldn’t think so since mean curvature is a differential property and so should be pretty local, but I guess controlling for overall curvature would be a slightly different hypothesis

Cheers

Bruce

From: freesurfer-bounces@nmr.mgh.harvard.edu <freesurfer-bounces@nmr.mgh.harvard.edu> On Behalf Of Letitia Schneider
Sent: Friday, November 27, 2020 8:56 AM
To: freesurfer@nmr.mgh.harvard.edu
Cc: Josue Luiz Dalboni Da Rocha <Josue.Dalboni@unige.ch>
Subject: [Freesurfer] Mean Curvature

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Dear Freesurfer team,

When I analyse the mean curvature value of a particular ROI, do I have to control for overall brain curvature, to make sure the results are not driven by individual differences in overall brain curvature? 

Best wishes,

Letitia Schneider