Are you doing 5 different tests or just one test? It is a tricky question as to whether you should correct across  5 tests or not. Ideally, one should, but I don't think I've ever seen it done in practice. As a reviewer, I might not demand it for only 5 tests.

      

Hello,

We have a question about using glm_fit in freesurfer.

When we model several covariates (behavioral scores) in glm, and we wanted to know the correlation between cortical thickness changes with the changes of behavioral scores.  We obtained the correlation results nicely after using freesurfer's monte carlo correction (eg. increase of behavioral scores is correlated with the increase of cortical thickness changes).

Should we still perform the bonefferi corrections on the results we got ?

(because we have entered 5 covariates into the glm model, so we are wondering if it is still needed to divide the alpha-value by 5 to determine the final significant findings)?

Thank you so much for helping us,

Jahanvi

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