Dear SAMSEG developers,

We have a dataset with 55 subjects (MS patients and controls) scanned on three timepoints with yearly intervals.

When we ran the (SAMSEG) longitudinal pipeline we noticed that the sbTIV always had an increased volume (between 0.5 and 3.5% larger) compared to the sbTIV computed cross-sectionally. Do you have any idea how and why we may see these effects?

Thank you in advance!

Best regards,

David van Nederpelt | Amsterdam UMC