The first one is a more complicated model that includes a mixed effects design. Harder to set up.
The second is a paired ttest; this is simple and  good if you only have two time points.
For three time points I would use https://surfer.nmr.mgh.harvard.edu/fswiki/RepeatedMeasuresAnova



On 2/13/2026 1:22 PM, Eszter Boros wrote:

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Dear FreeSurfer Team,

We are trying to run some longitudinal data using FreeSurfer 7.4.1.
We have one group and 3 scans. We would like to see the changes between these timepoints. 
I am not sure how to proceed with the GLM because I found two tutorials.

One here is saying I should create a longitudinal qdec table including fsid-base column and years/timepoints then run mri_glmfit --osgm
https://surfer.nmr.mgh.harvard.edu/fswiki/LongitudinalTwoStageModel

The other one is saying to do a paired analysis. This one does not include the base and years data. 
https://surfer.nmr.mgh.harvard.edu/fswiki/PairedAnalysis

How should I proceed?
Thank you!

Best regards,
Eszter



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