Then, and finally is this method the best way to determine whether exist any cortical thickness anomaly, I mean, to use a normal  control acquisition as comparisson?

Thanks in advance
Ignacio.
2011/7/5 Bruce Fischl <fischl@nmr.mgh.harvard.edu>
Hi Ignacio,

the thickness is definitely affected by factors such as sequence type, field strength and acquisition parameters (not to mention age, maybe gender, etc...) so I think you need to acquire your own control(s) on a matched acquisition.

cheers.
Bruce


 On Tue, 5 Jul 2011, Ignacio Letelier wrote:

Hi Bruce,

Otherwise, is it possible to simply compare my T1 brain acquisition  (with
dysplasia suspicion) with a 'normal template' (which maybe bert) to
determine whether there exist any  anomaly in the cortical thickness ? and,
is it possible to visualize these potential differences using a color map
scaling?

Thanks in advance-

Best regards.

Ignacio.

2011/7/3 Bruce Fischl <fischl@nmr.mgh.harvard.edu>
     Hi Ignacio,

     I see. You could do that, but I don't think it will show what
     you want. There is a big geometric component to the thickness -
     crowns are thick and fund are thin - so at the very least you
     might try including mean curvature as a covariate.


cheers
Bruce

On Fri, 1 Jul 2011, Ignacio Letelier wrote:

     Sorry I didn't realize since you have the same domain.

     Ok, Let's say I do know the mean cortical thickness value
     of a subject. Then
     is it possible know  what brain areas differ more from
     that mean value by
     using a color map visualization (I.e.  for example: red =
     higher deviations,
     deep blue = lower deviations)? So this way I can determine
     where there may
     exist some kind of dysplasia.

     Best regards.

     2011/7/1 Bruce Fischl <fischl@nmr.mgh.harvard.edu>
          can you post this kind of thing so others can answer?
     I still
          don't understand though. stdv of what?


     On Fri, 1 Jul 2011, Ignacio Letelier wrote:

          Let's say I want to know if there is a way to know
     where
          is the highest stdv in the same subject, using a
     color map
          visualization in qdec or something?

          Best regards.

          2011/7/1 Bruce Fischl <fischl@nmr.mgh.harvard.edu>
               Hi Ignacio

               you mean different from the median in that
     subject?
          Easy enough to do in matlab, but we don't have
     anything
          out of the box to do it

               cheers
               Bruce

          On Fri, 1 Jul 2011, Ignacio Letelier wrote:

               Hi forum

               Is it possible to get statistical maps of 
     cortical
          thickness differences in the same subject? I.e. to
     know
          what areas differ most from the median


               --
               Ignacio




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