Dear FreeSurfers,

We are comparing two methods to measure the volume of a subcortical structure (our method and FreeSurfer). We want to compare them spatially, by doing a voxel-based analyses.

We thought to isolate the structure from the aseg.mgh as well as our own structure. Then we smoothed both data sets.

Now we are trying to convert the structure from our method to FreeSurfer space (256 x 256). Then, our plan was to put all the data of the structures of both methods all the subjects together (4D) and to run mri_glmfit (comparing method one with method two).

Does this seems logically?

But, we were wondering how we should deal with the warping towards the fsaverage (which is ofcourse not similar to the subcortical structure) in the mri_glmfit?

Do you have any idea?

Thank you very much.

Best

Heidi Jacobs

Heidi Jacobs, MSc.
PhD student
Faculty of Health, Medicine and Life Sciences

School for Mental Health and Neurosciences

Alzheimer Center Limburg

Division Cognitive Neuropsychiatry and Clinical Neurosciences
h.jacobs@maastrichtuniversity.nl
www.maastrichtuniversity.nl

Dr. Tanslaan 12, 6229 ET Maastricht
P.O. Box 616, 6200 MD Maastricht, The Netherlands
T +31 43 38 84 126 F +31 43 38 84 092

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